CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Cancer: Genome Instability and Mutation

Not all cancer cells are equal, they evolve in response to selective pressure driven by accumulation...
Chris Sumner Aug 28, 2019

Hallmarks of Cancer: Tumor-Promoting Inflammation

Cancer cells hijack inflammatory mechanisms to promote their own growth and survival. During a norma...
Chris Sumner Aug 21, 2019

Hallmarks of Cancer: Activation Invasion and Metastasis

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes...
Chris Sumner Jul 17, 2019

Immunotherapy & CAR-T Cells

Our immune system has the ability to detect and fight infectious pathogens. It can also detect when ...
Chris Sumner Jul 10, 2019

Hallmarks of Cancer: Avoiding Immune Destruction

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. O...
Chris Sumner Jun 12, 2019

Who am I: Can a cellular identity crisis lead to cancer progression?

The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells tran...
Antony Wood, PhD May 29, 2019

Hallmarks of Cancer: Evading Growth Suppressors

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways in...
Chris Sumner May 1, 2019

Hallmarks of Cancer: Enabling Replicative Immortality

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cell...
Chris Sumner Apr 17, 2019

Hallmarks of Cancer: Sustaining Proliferative Signaling

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals a...
Chris Sumner Apr 3, 2019

Hypoxia and Cancer: The role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions ...
Jianxin Xie, PhD Mar 27, 2019

Hallmarks of Cancer: Inducing Angiogenesis Energetics

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is th...
Chris Sumner Mar 20, 2019

Hallmarks of Cancer: Deregulating Cellular Energetics

Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.
Chris Sumner Feb 27, 2019

More Than a Phenotype: A Guide to Assessing Tumor-infiltrating Immune Cell Types and Functions

Although the rise of cancer immunotherapy may seem meteoric to many, the history goes back over 100 ...
Emily A Feb 6, 2019

Hallmarks of Cancer: Resisting Cell Death

One thing we know about cancer cells: they can resist death. They evade apoptosis, the mechanism tha...
Chris Sumner Jan 23, 2019

Demystifying Antibody Panel Design for Multiplex IHC

In recent years, immune checkpoint proteins in the tumor microenvironment have been under intense st...
Jen Z Oct 10, 2018

2018 Nobel Prize Awarded to Immunotherapy Pioneers

Earlier this week, Dr. James Allison and Dr. Tasuku Honjo were announced as joint winners of the 201...

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