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The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Cancer: Senescent Cells

Senescence, a stable and generally irreversible state of cell cycle arrest, is a double-edged sword ...
Susan Keezer, PhDJan 14, 2026

Mechanisms of Cell Death: Ferroptosis

What is ferroptosis? Ferroptosis is an iron-dependent form of programmed cell death with distinct mo...
Gary Kasof, PhDJul 9, 2025

Mechanisms of Cell Death: Apoptosis

What is apoptosis? Apoptosis is a form of programmed cell death (PCD) characterized by cell shrinkag...
Gary Kasof, PhDJun 18, 2025

It’s a Cell-Eat-Self World: ULK1, AMPK & mTOR Signaling in Autophagy

If the thought of self-cannibalization is not appealing to you, you may not want to read the next se...
Alexandra FoleyMay 22, 2024

How to Control Your Apoptosis, Autophagy, & Mitophagy Western Blots

Have you ever spent time treating cells, preparing cell extracts, and performing a western blot only...
Whitney PalmerDec 4, 2023

IHC-Validated p16INK4A Antibody: Jump-Start Your Senescence Research

p16INK4A has become a widely used marker for identifying senescent cells in tissue, yet interpreting...
Andrea Tu, PhDApr 19, 2023

Emerging Discoveries in ER-Phagy

Autophagy is a catabolic process for the disposal of cytoplasmic contents that are captured by doubl...
Gary Kasof, PhDNov 3, 2021

Assay Kits and Tools for Monitoring Cell State

Have you been wondering how to monitor a cell state or cellular response? From a basic research stan...
Andrea Tu, PhDOct 6, 2021

Understanding Mitophagy: Pathways, Disease Links, and Tools for Detection

Mitochondrial health is a complex, carefully regulated process involving pathways that determine mit...
Gary Kasof, PhDAug 11, 2021

Autophagy: Taking Out the Cellular Trash Has Widespread Therapeutic Implications

The term “autophagy” introduced by the biochemist Christian de Duve in 1963 is derived from the Gree...
Gary Kasof, PhDJun 16, 2021

Mechanisms of Cell Death: Necrosis & Necroptosis

The thought of necrotic cell death might bring to mind images from an old horror movie, but as with ...
April Lowell, PhDApr 28, 2021

Mechanisms of Cell Death: Pyroptosis

Pyroptosis is a form of regulated necrotic cell death that ties the danger-sensing capabilities of t...
Gary Kasof, PhDApr 7, 2021

The Role of Autophagy and ER Stress in Viral Infection

The regulation of ER stress and autophagy during viral infection is an important factor in the balan...
Gary Kasof, PhDOct 28, 2020

The Role of Cell Death in Viral Infection

The regulation of cell death during viral infection is an important factor in the balance of virus a...
Gary Kasof, PhDOct 21, 2020

Which markers can be used to identify cellular senescence?

In response to a variety of environmental factors—like ionizing radiation, exposure to chemotherapeu...
Tamar Aprahamian, PhDOct 14, 2020

Cell Process: What role does senescence play in disease?

Cellular senescence occurs when cells cease proliferation and irreversibly exit the cell cycle. Whil...

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