Cell Process: Which markers can be used to identify cellular senescence?


Posted by Tamar A. on Oct 14, 2020 3:00:00 AM

In response to a variety of environmental factors – like ionizing radiation, exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, or oncogene activation – cells may permanently cease proliferation and enter a state known as cellular senescence. Senescence occurs during normal developmental processes, in wound healing, and as a consequence of aging and age-related disease. Accordingly, understanding why senescence contributes to these processes may lead to the development of pro- and anti-senescence therapies to treat a range of diseases.

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Topics: Cell Biology

Cell Process: What role does senescence play in disease?


Posted by Tamar A. on Oct 7, 2020 3:00:00 AM

Cellular senescence occurs when cells cease proliferation and irreversibly exit the cell cycle. While this occurs as a normal process during development and tissue remodeling, senescence has also been linked to a general decline in tissue function during aging as well as a number of disease states. These include the progression of cancer, atherosclerosis, diabetes, and neurodegeneration. Accordingly, understanding why senescent cells impact these conditions and developing ways to target their removal may provide therapeutic value for the treatment of many human conditions.

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Topics: Cell Biology

Cell Process: What role do the telomeres play in senescence?


Posted by Tamar A. on Sep 16, 2020 3:00:00 AM

Senescence is a cellular state during which cells remain metabolically active, but irreversibly withdraw from the cell cycle and fail to respond to proliferation-inducing stimuli. Senescent cells influence a number of physiological and pathological processes from cancer to diabetes and aging. Accordingly, understanding why senescence contributes to these conditions may lead to the development of pro- and anti-senescence therapies to treat a range of diseases.

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Topics: Cell Biology

Cell Process: How is cellular senescence related to aging?


Posted by Tamar A. on Sep 9, 2020 3:00:00 AM

Senescence, the cessation of cell division and permanent withdrawal from the cell cycle, is a process that occurs throughout the lifespan — during embryogenesis, growth and development, tissue remodeling, and in wound healing. Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age related diseases. These include metabolic and cardiovascular disorders, neurodegenerative disease, and cancer. In mammals, aging causes the gradual dysfunction of multiple tissue systems in a heterogeneous fashion, ultimately leading to death. Understanding how and why senescence contributes to the aging process may lead to therapies to slow or even reverse its progression.

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Topics: Cell Biology

Cell Process: What signaling pathways are associated with cellular senescence?


Posted by Tamar A. on Aug 26, 2020 3:00:00 AM

Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways, as well that the secretion of proteins that affect the surrounding tissue microenvironment. Most notably, senescent cells exhibit a persistent DNA damage response, the activation of proteins which control cell cycle arrest, and the senescence associated secretory phenotype. Senescent cells are also resistant to apoptosis and demonstrate altered metabolic activity. Determining why changes in cellular signaling lead to senescence is key to understanding how senescence contributes to normal and pathological processes affecting human health.

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Topics: Cell Biology

Cell Process: What is cell senescence?


Posted by Tamar A. on Aug 12, 2020 3:00:00 AM

Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. Senescence is triggered by a variety of cellular stressors. These include environmental factors like ionizing radiation or exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, and oncogene activation. This process provides a defense mechanism to maintain tissue homeostasis through the sequestration of damaged cells. Senescent cells influence a number of physiological and pathological processes from cancer to diabetes and aging. Accordingly, understanding why senescence contributes to these conditions may lead to the development of pro- and anti-senescence therapies to treat a range of diseases.

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Topics: Cell Biology

How can recombinant proteins help researchers study SARS-CoV-2?


Posted by Tamar A. on Aug 5, 2020 3:15:00 AM

Although coronaviruses have long circulated throughout human populations, the study of these viruses has intensified over the last two decades, due to the rise of novel coronaviruses that have greatly impacted human health. The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle East respiratory syndrome-related coronavirus (MERS-CoV) in 2012, and the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, has emphasized the importance of understanding the fundamental mechanisms by which these viruses cause disease.

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Topics: Immunology

Cell Process: How is cytotoxicity assessed?


Posted by Tamar A. on Jul 8, 2020 3:00:00 AM

Changes in cellular health in response to exogenous stimuli can provide keen insight into the biological mechanisms that govern the relationship between cells and their environment and can dramatically influence the interpretation of experimental results. These reasons underscore why it is important to understand cytotoxicity and to employ assays to measure its impact.

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Topics: Cell Biology

Cell Process: The seven best assays to detect apoptosis


Posted by Tamar A. on Jul 1, 2020 3:00:00 AM

Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms during development, throughout the lifespan, and in response to cellular stress. Nuclear condensation, cell shrinkage, membrane blebbing, and DNA fragmentation are characteristic features of the cellular disassembly that occurs during this form of cell death. A family of proteolytic enzymes, called caspases, serves as the central regulators of apoptosis, and their activity, in turn, is balanced by myriad additional pro-apoptotic and anti-apoptotic proteins. The dysregulation of apoptosis occurs in and contributes to the pathology of several disease states, including autoimmune disorders, neurodegenerative diseases, and cancer. Therefore, understanding how and why apoptosis influences these biological processes may lead to advances in therapies to treat and benefit human health.

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Topics: Cell Biology

Immunology: What are toll-like receptors and how do they invoke tumor tolerance?


Posted by Tamar A. on Jun 10, 2020 3:00:00 AM

Toll-like receptors (TLR) are transmembrane receptors that play a critical role in innate immune responses. The name derives from the homology to the Drosophila Toll gene; unlike adaptive immunity which evolved in the vertebrate lineage, innate immunity exists (and is conserved) in invertebrate branches.

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Topics: Immunology

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