CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Microglial Activation Antibody Toolkit: High-Content Methods to Study TREM2 Signaling

Selecting antibodies for molecular signaling research in neurodegeneration is a complex and nuanced ...
Ginny Bain, PhD Dec 11, 2024

Unraveling Alzheimer’s Disease: Developing a P-Tau 217 Antibody

With Alzheimer’s disease (AD) set to affect more than 7.1 million people over 65 worldwide by 2025, ...
Arica Aiello Aug 14, 2024

Multiplexed Methods for Studying the Spatial Biology of the Brain

Cases of neurodegeneration and dementia are predicted to rise with the aging population, yet conditi...
Richard Cho, PhD Aug 7, 2024

Characterizing the Autophagic-Lysosomal Pathway in Parkinson’s Disease

We’re proud to partner with The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to move PD...

A Quick Guide to Neuronal and Glial Cell Type Markers

The central nervous system (CNS) is composed of highly specialized cells, each of which play a key r...
Supriya Singh, PhD Jul 12, 2023

Unraveling Parkinson’s Disease: The Role of Mitophagy, Autophagy & Lysosomal Processing

We’re proud to partner with The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to move Pa...

AD/PD 2023: Therapeutics, Diagnostics & Mechanisms Linked to a Classic Alzheimer’s Disease Theory

The amyloid cascade hypothesis1, a theory initially proposed over 30 years ago, continues to be the ...
Jordan Hirschfeld Jun 7, 2023

Stress Granules: What are they and what role do they play in neurodegenerative diseases?

Stress granules (SGs) are an important cellular defense mechanism against stress. Their formation is...
Jordan Hoffman May 24, 2023

SfN 2022: Ups and Downs in Neurodegenerative Research—New Tools, Models, and Technologies

In November, nearly 25,000 neuroscientists from all over the world gathered once again for the Socie...
Richard Cho, PhD Jan 6, 2023

Multiplexing the Brain: A Galaxy of Possibilities

The average human brain contains over 100 billion cells, which is nearly the same number as there ar...
Richard Cho, PhD Dec 15, 2021

Neuroinflammation in Neurodegenerative Diseases

Neuroinflammation is the activation of an immune response in the central nervous system (CNS; brain ...
Chris Sumner Jun 23, 2021

Autophagy: Taking Out the Cellular Trash Has Widespread Therapeutic Implications

The term “autophagy” introduced by the biochemist Christian de Duve in 1963 is derived from the Gree...
Gary Kasof, PhD Jun 16, 2021

Neurotransmitters, Receptors, and Transporters

Neurons are central nervous system (CNS) cells that receive and transmit electrochemical signals by ...
Chris Sumner May 19, 2021

Which Antibody-Based Techniques Can Be Used to Study Neurodegenerative Diseases?

In order to derive the most information from samples related to neurodegenerative disease, it is imp...
Chris Sumner Mar 17, 2021

Neurodegeneration: Tau Protein and Neurofibrillary Tangles

Tau is a microtubule-associated protein expressed predominantly in the parts of the brain that funct...
Chris Sumner Feb 10, 2021

What Is Neurodegenerative Disease?

Neurodegeneration is marked by the progressive loss of neuronal function and structure leading to co...
Chris Sumner Jan 20, 2021

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