B Cell Basics:  What a disease researcher needs to know


Posted by Tamar A. on Nov 18, 2020 3:15:00 AM

Changes in the activation of intracellular signaling networks downstream of B cell receptors (BCR) lead to altered B cell phenotypes. Knowledge of this process, and B cell plasticity, is essential for understanding how B cells modulate the immune response.

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Topics: Immunology

T Cell Basics: What a disease researcher needs to know


Posted by Tamar A. on Nov 11, 2020 3:00:00 AM

T cells are highly specialized lymphocytes that play a critical role in the cell-mediated arm of the adaptive immune response. Without them, our bodies would not be able to successfully fight off viral infections or scour tissues to eliminate some pre-cancerous cells.

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Topics: Immunology

COVID-19 and Fibrosis: Long-term damage beyond acute respiratory symptoms


Posted by Tony W on Nov 4, 2020 3:00:00 AM

At the time of writing the SARS-CoV-2 virus, responsible for COVID-19, has infected more than 28 million people worldwide, with nearly a million deaths attributed to the virus (source: Johns Hopkins Coronavirus Resource Center). One of the most striking aspects of SARS-CoV-2 infection is the diversity of symptoms that have been reported in patients [Kwon, 2020].

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Topics: Immunology

How can recombinant proteins help researchers study SARS-CoV-2?


Posted by Tamar A. on Aug 5, 2020 3:15:00 AM

Although coronaviruses have long circulated throughout human populations, the study of these viruses has intensified over the last two decades, due to the rise of novel coronaviruses that have greatly impacted human health. The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, Middle East respiratory syndrome-related coronavirus (MERS-CoV) in 2012, and the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, has emphasized the importance of understanding the fundamental mechanisms by which these viruses cause disease.

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Topics: Immunology

Immunology: How does the adaptive immune system work?


Posted by April L on Jul 29, 2020 3:00:00 AM

Have you ever wondered how people are able to develop immunity to specific diseases? This important question has been the focus of many critical medical and immunological research endeavors. The answer is that it’s all due to the cells and antibodies of the adaptive immune system.

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Topics: Immunology

Protect Your Pipeline: Don't let antibody supply disrupt your progress


Posted by Josh N on Jun 17, 2020 3:00:00 AM

During the pandemic, supply shortages took many of us by surprise. Who would have thought items as diverse as webcams and toilet paper would become nearly impossible to buy?

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Topics: Antibody Performance, Antibody Validation, Immunology

Immunology: What are toll-like receptors and how do they invoke tumor tolerance?


Posted by Tamar A. on Jun 10, 2020 3:00:00 AM

Toll-like receptors (TLR) are transmembrane receptors that play a critical role in innate immune responses. The name derives from the homology to the Drosophila Toll gene; unlike adaptive immunity which evolved in the vertebrate lineage, innate immunity exists (and is conserved) in invertebrate branches.

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Topics: Immunology

Immunology: Can we re-train our T cells to attack cancer?


Posted by Tamar A. on Jun 3, 2020 3:00:00 AM

The human immune system comprises an array of ingenious cellular components and mechanisms that collectively protect us from harmful exogenous pathogens. Harnessing this power to attack and treat cancer is an intense area of research. Understanding why cancer cells normally evade immune surveillance and developing strategies to help the immune system distinguish between tumor cells and healthy tissue may lead to the development of highly efficacious therapies for those afflicted with cancer.

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Topics: Immunology

Immunology: What cells have a myeloid lineage and how are they identified?


Posted by Tamar A. on May 27, 2020 3:00:00 AM

During haematopoiesis in humans, cells of the myeloid lineage are derived from a common myeloid progenitor (CMP) in the bone marrow. This lineage — which includes monocytes, granulocytes, erythrocytes, and platelets — is a primary component of the innate immune system and serves as a first line of defense against infection.

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Topics: Immunology

Immunology: How does the innate immune system work?


Posted by April L on Feb 12, 2020 3:15:00 AM

As we touched upon in a previous blog post, the innate immune system is an important part of our bodies’ immune defenses and it provides us with a general protective response against microbial invaders and foreign proteins. This innate immune system is evolutionarily older than our adaptive immune system, with conserved mechanisms seen in plants, animals, and insects, and it is not specialized against any particular pathogen.

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Topics: Immunology

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