CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST) where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Immunology: Which Cells Have a Lymphoid Lineage and How Are They Identified?

In humans, hematopoietic stem cells (HSCs) continuously replenish all types of blood cells via a ser...
Emma E Jan 19, 2022

Tools for Monitoring Cell State

Have you been wondering how to monitor a cell state or cellular response? From a basic research stan...
Andrea Tu, PhD Oct 6, 2021

Immunology: Immunophenotyping Basics

Immunophenotyping is a technique that uses antibodies to allow the identification and quantification...
Chris Sumner Jun 30, 2021

Targeting TIGIT for Immunotherapy and T Cell Exhaustion

The evolution of solid tumor cancer treatment has historically centered on a tripartite approach tha...
Tamar A Feb 17, 2021

B Cell Basics: What a Disease Researcher Needs to Know

Changes in the activation of intracellular signaling networks downstream of B-cell receptors (BCR) l...
Tamar A Nov 18, 2020

T Cell Basics: What a Disease Researcher Needs to Know

T cells are highly specialized lymphocytes that play a critical role in the cell-mediated arm of the...
Tamar A Nov 11, 2020

COVID-19 and Fibrosis: Long-term damage beyond acute respiratory symptoms

At the time of writing the SARS-CoV-2 virus, responsible for COVID-19, has infected more than 28 mil...
Antony Wood, PhD Nov 4, 2020

How can recombinant proteins help researchers study SARS-CoV-2?

Although coronaviruses have long circulated throughout human populations, the study of these viruses...
Tamar A Aug 5, 2020

Immunology: How Does the Adaptive Immune System Work?

Have you ever wondered how people are able to develop immunity to specific diseases? This important ...
April Lowell, PhD Jul 29, 2020

Protect Your Pipeline: Don't let antibody supply disrupt your progress

During the pandemic, supply shortages took many of us by surprise. Who would have thought items as d...
Josh N Jun 17, 2020

Immunology: What are toll-like receptors and how do they invoke tumor tolerance?

Toll-like receptors (TLR) are transmembrane receptors that play a critical role in innate immune res...
Tamar A Jun 10, 2020

Immunology: Which cells have a myeloid lineage and how are they identified?

During hematopoiesis in humans, cells of the myeloid lineage are derived from a common myeloid proge...
Tamar A May 27, 2020

Immunology: How Does the Innate Immune System Work?

As we touched upon in a previous blog post, the innate immune system is an important part of our bod...
April Lowell, PhD Feb 12, 2020

Immunology Overview: How does our immune system protect us?

Scientists and medical professionals have been studying what makes us sick and the myriad mechanisms...
April Lowell, PhD Jan 8, 2020

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar A Sep 25, 2019

Immunotherapy & CAR-T Cells

Our immune system has the ability to detect and fight infectious pathogens. It can also detect when ...
Chris Sumner Jul 10, 2019

More Than a Phenotype: a Guide to Assessing Tumor-infiltrating Immune Cell Types and Functions

Although the rise of cancer immunotherapy may seem meteoric to many, the history goes back over 100 ...
Emily A Feb 6, 2019

Demystifying Antibody Panel Design for Multiplex IHC

In recent years, immune checkpoint proteins in the tumor microenvironment have been under intense st...
Jen Z Oct 10, 2018

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