CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology® (CST) where we discuss what to expect from your time at the bench, share tips, tricks, and information.

Targeting TIGIT for Immunotherapy and T Cell Exhaustion

The evolution of solid tumor cancer treatment has historically centered on a tripartite approach tha...
Tamar A. Feb 17, 2021 3:00:00 AM

B Cell Basics:  What a disease researcher needs to know

Changes in the activation of intracellular signaling networks downstream of B cell receptors (BCR) l...
Tamar A. Nov 18, 2020 3:15:00 AM

T Cell Basics: What a disease researcher needs to know

T cells are highly specialized lymphocytes that play a critical role in the cell-mediated arm of the...
Tamar A. Nov 11, 2020 3:00:00 AM

COVID-19 and Fibrosis: Long-term damage beyond acute respiratory symptoms

At the time of writing the SARS-CoV-2 virus, responsible for COVID-19, has infected more than 28 mil...
Tony W Nov 4, 2020 3:00:00 AM

How can recombinant proteins help researchers study SARS-CoV-2?

Although coronaviruses have long circulated throughout human populations, the study of these viruses...
Tamar A. Aug 5, 2020 3:15:00 AM

Immunology: How does the adaptive immune system work?

Have you ever wondered how people are able to develop immunity to specific diseases? This important ...
April L Jul 29, 2020 3:00:00 AM

Protect Your Pipeline: Don't let antibody supply disrupt your progress

During the pandemic, supply shortages took many of us by surprise. Who would have thought items as d...
Josh N Jun 17, 2020 3:00:00 AM

Immunology: What are toll-like receptors and how do they invoke tumor tolerance?

Toll-like receptors (TLR) are transmembrane receptors that play a critical role in innate immune res...
Tamar A. Jun 10, 2020 3:00:00 AM

Immunology: Can we re-train our T cells to attack cancer?

The human immune system comprises an array of ingenious cellular components and mechanisms that coll...
Tamar A. Jun 3, 2020 3:00:00 AM

Immunology: What cells have a myeloid lineage and how are they identified?

During haematopoiesis in humans, cells of the myeloid lineage are derived from a common myeloid prog...
Tamar A. May 27, 2020 3:00:00 AM

Immunology: How does the innate immune system work?

As we touched upon in a previous blog post, the innate immune system is an important part of our bod...
April L Feb 12, 2020 3:15:00 AM

Immunology Overview: How does our immune system protect us?

Scientists and medical professionals have been studying what makes us sick and the myriad mechanisms...
April L Jan 8, 2020 3:15:00 AM

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar A. Sep 25, 2019 3:15:00 AM

More Than a Phenotype: a Guide to Assessing Tumor-infiltrating Immune Cell Types and Functions

Although the rise of cancer immunotherapy may seem meteoric to many, the history goes back over 100 ...
Emily A. Feb 6, 2019 3:05:00 AM

Demystifying Multiplex IHC

In recent years, immune checkpoint proteins in the tumor microenvironment have been under intense st...
Jen Z Oct 10, 2018 3:15:00 AM

Video: Understanding Macrophages in the Tumor Microenvironment

Research trends in macrophage plasticity It’s an exciting time for immuno-oncology research, as pote...
Ken B Sep 19, 2018 3:15:00 AM

Targeting B-Cell Maturation Antigen (BCMA) Holds Promise for Multiple Myeloma Cure

Multiple myeloma (MM) is a type of hematopoietic malignancy characterized, in part, by bone pain, an...
Amrik S. Aug 8, 2018 3:10:00 AM

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