Lab Expectations

Fibrosis is a disease that is characterized by scarring and hardening of tissues and organs. Fibrosis can affect all tissues of the body, and left unchecked, can result in organ failure and death. What causes it? Believe it or not, it is a process that stems from wound healing that has gone awry.

In order to quickly defeat SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2，previously named as nCoV) and stop the epidemic, diagnosis and treatment are especially important. As of January 31, 2020, SARS-CoV-2 nucleic acid detection kits from 7 companies have been approved for SARS-CoV-2 detection (data source: NMPA). Meanwhile, researchers are still working hard to develop effective treatments.

If you haven’t heard already, it’s CST’s 20^th anniversary. Woohoo! You could say this year is kind of a big deal for us. We have a lot to celebrate. However, once we started listing the successes over the years, we realized that we are most proud of what you – the researchers worldwide – have accomplished using our reagents. After all, we don’t live in a vacuum. We exist to serve you and enable important discoveries and the development of cures.

Not all cancer cells are equal, they evolve in response to selective pressure driven by accumulation of mutations. Cancer cells have to out-compete nearby cells for nutrients and other resources, avoid immune cell attack, and suppress apoptotic self-destruction.

Cancer cells hijack inflammatory mechanisms to promote their own growth and survival. During a normal inflammatory response by the innate and adaptive immune system, immune cells carry out their designated task of engulfing and/or destroying foreign invaders.

Gain insight into the processes by which senescent cells contribute to tumor suppression and age-related pathologies. This webinar explores the impact of senescence on age-related dysfunction and chronic disease and introduces potential therapies targeting senescent cells.

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. One way cells do this is by hijacking normal mechanisms of immune checkpoint control and modulation of the innate immune response via STING.

            The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells transform into cells with more mesenchymal characteristics, was first described by pioneering Harvard biologist Elizabeth “Betty” Hay in the 1980s.

Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to the normal aging process as well as age-related disorders. The link between senescence, aging, and age-related pathologies, including cancer, neurodegeneration, and metabolic and cardiovascular diseases have largely fueled the senescence research field.