Hallmarks of Cancer: Activation Invasion and Metastasis


Posted by Chris S on Jul 17, 2019 3:15:00 AM

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.

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Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Avoiding Immune Destruction


Posted by Chris S on Jun 12, 2019 3:15:00 AM

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. One way cells do this is by hijacking normal mechanisms of immune checkpoint control and modulation of the innate immune response via STING.

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Topics: Cell Biology, Cancer Research

Who am I: Can a cellular identity crisis lead to cancer progression?


Posted by Antony W on May 29, 2019 3:10:00 AM

            The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells transform into cells with more mesenchymal characteristics, was first described by pioneering Harvard biologist Elizabeth “Betty” Hay in the 1980s.

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Topics: Cell Biology, Cancer Research

What is Senescence?


Posted by Susan K on May 22, 2019 3:15:00 AM

Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to the normal aging process as well as age-related disorders. The link between senescence, aging, and age-related pathologies, including cancer, neurodegeneration, and metabolic and cardiovascular diseases have largely fueled the senescence research field.

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Topics: Cell Biology

Hallmarks of Cancer: Evading Growth Suppressors


Posted by Chris S on May 1, 2019 3:10:00 AM

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Death Receptor Signaling (Apoptosis), both of which can ultimately lead to cell death, and reduction in tumor growth.

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Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Enabling Replicative Immortality


Posted by Chris S on Apr 17, 2019 3:10:00 AM

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions.

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Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Sustaining Proliferative Signaling


Posted by Chris S on Apr 3, 2019 3:15:00 AM

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.

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Topics: Cell Biology, Cancer Research

Hypoxia and Cancer – the role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis


Posted by Jianxin X. on Mar 27, 2019 3:10:00 AM

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP.

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Topics: Metabolism, Cell Biology

Hallmarks of Cancer: Inducing Angiogenesis Energetics


Posted by Chris S on Mar 20, 2019 3:15:00 AM

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.

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Topics: Cell Biology, Cancer Research

Necroptosis and Pyroptosis Add to Our Understanding of Apoptotic Cell Death


Posted by Gary K. on Mar 13, 2019 3:05:00 AM

Over the last 50 years laboratories have been able to demonstrate through experimentation the processes contributing to cell death. Early discoveries focused on morphological features of cell death and classifications into apoptosis and necrosis. Since then, there have been many more discoveries regarding the programmed cellular pathways contributing to apoptosis.

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Topics: Cell Biology

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