PI3K/Akt Signaling Targets Hit Close to Home

Posted by Srikanth S on Aug 19, 2020 3:00:00 AM

The ability of cells to recognize external signal cues (ligands and nutrients) and appropriately respond to a rapidly changing environment involves crosstalk among major cellular signaling networks (1-2). These complex pathways sense intracellular nutrients, metabolic flux, and stress and integrate these distinct signals through numerous downstream effectors (1-2). As a scientist, I find trying to understand the intricate nature of pathways (where they overlap and intersect) to be an interesting puzzle to tease apart.


Topics: Cell Biology

The Importance of Research Antibody Specificity and Reproducibility During the SARS-CoV-2 Crisis

Posted by Srikanth S on May 6, 2020 3:38:00 PM

During this time of crisis, healthcare providers and researchers around the world are racing to develop SARS-CoV-2 testing methods. Testing strategies include PCR to diagnose active infection (by testing for the presence of viral genetic material) and the use of antibody test kits on blood (also known as serological tests), in order to track exposure and possible immunity in the population (1,2,3). With these diagnostic tools, the scientific community aims to get a better understanding of the scale and trajectory of the SARS-CoV-2 pandemic.


Topics: Antibody Performance, Antibody Validation, Reproducibility

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