CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Targeting the Tumor Microenvironment: Key Markers of the Extracellular Matrix (ECM)

In recent years, cancer researchers have started paying closer attention to the extracellular matrix...
Susan Keezer, PhD May 28, 2025

Spatial Insights for CAR-Engineered Cells in Solid Tumors: Antibody-Based CAR Detection Method

Cell Signaling Technology provides products and services are for research use only and not for use i...
Amrik Singh, PhD Apr 16, 2025

Multiplexed Methods for Studying the Spatial Biology of the Brain

Cases of neurodegeneration and dementia are predicted to rise with the aging population, yet conditi...
Richard Cho, PhD Aug 7, 2024

Antibody Validation for IHC: Finding a Claudin-6 mAb Clone

Developing research antibodies is an extensive process that takes advantage of an animal’s adaptive ...
Alexandra Foley Nov 15, 2023

SignalStar® Multiplex IHC: Speed Your Spatial Biology Research with Ready-to-Use, 8-Plex Antibody Panels

Enabled by recent advances in sequencing, mass spectrometry, and fluorescence microscopy, spatial bi...
Sarah Klein, PhD Sep 12, 2023

IHC-Validated p16 INK4A Antibody: Jump-Start Your Senescence Research

Cell cycle regulation is vital to maintain tissue homeostasis and to prevent sustained proliferative...
Andrea Tu, PhD Apr 19, 2023

CST® Antibodies Validated on the Leica Microsystems Cell DIVE Multiplexed Imaging Solution

True innovation comes from collaboration–from bringing experts together to create techniques and too...
Alexandra Foley Mar 15, 2023

World Cancer Day: A Global Call to Action

Most people will either be directly or indirectly affected by a cancer diagnosis at some point in th...
Alexandra Foley Feb 6, 2023

Immunology: Immunophenotyping Using Flow Cytometry or IHC

In the field of immunology and immuno-oncology, immunophenotyping is a technique that uses antibodie...
Chris Sumner Jun 30, 2021

Cancer Biomarker Antibody Selection for IHC

What are cancer biomarkers? Biomarkers are naturally occurring molecules that can be used as indicat...

Targeting TIGIT for Cancer Immunotherapy & T Cell Exhaustion

The evolution of solid tumor cancer treatment has historically centered on a tripartite approach tha...
Tamar Aprahamian, PhD Feb 17, 2021

Pros and Cons of Different Multiplexing Techniques for IHC and IF

Multiplex immunohistochemistry (mIHC) and multiplex immunofluorescence (mIF) are widely used to iden...

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar Aprahamian, PhD Sep 25, 2019

If I Could Only See What’s Going on Inside Your Brain...

For generations of neuroscientists, using immunohistochemistry to study the brain in its anatomical ...
Richard Cho, PhD Jun 5, 2019

Demystifying Antibody Panel Design for Multiplex IHC

In recent years, immune checkpoints in the tumor microenvironment have been under intense study. If ...
Jen Z Oct 10, 2018

Four Steps to Better Immunohistochemistry: Steps 2, 3, and 4

This is part two of a two-part series on how to optimize your immunohistochemistry (IHC) protocols. ...
Carolyn P Jul 15, 2015

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