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The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Unlock the Missing Marker: Three Ways to Expand Your Multiplex IHC Panel

If you’re running complex multiplex IHC on precious FFPE samples, you already know the tradeoff: eve...
Kelsey Goldman May 20, 2026

Antibody Compatibility Trifecta: Choosing a Multiplexing Strategy for Reliable Spatial Biology Insights

Spatially resolved multiplex detection links cellular phenotype and function to tissue architecture,...
Alexandra Foley Mar 4, 2026

More Than a Phenotype: Assessing Tumor-Infiltrating Immune Cell Type & Function

Although the rise of cancer immunotherapy may seem meteoric to many, the history actually stretches ...
Emily Alonzo, PhD Jan 7, 2026

Spatial Insights for CAR-Engineered Cells in Solid Tumors: Antibody-Based CAR Detection Method

Cell Signaling Technology provides products and services are for research use only and not for use i...
Amrik Singh, PhD Apr 16, 2025

Multiplexed Methods for Studying the Spatial Biology of the Brain

Cases of neurodegeneration and dementia are predicted to rise with the aging population, yet conditi...
Richard Cho, PhD Aug 7, 2024

Antibody Validation for IHC: Finding a Claudin-6 Monoclonal Antibody Clone

Developing research antibodies is an extensive process that takes advantage of an animal’s adaptive ...
Alexandra Foley Nov 15, 2023

SignalStar® Multiplex IHC: Speed Your Spatial Biology Research with Ready-to-Use, 8-Plex Antibody Panels

Enabled by recent advances in sequencing, mass spectrometry, and fluorescence microscopy, spatial bi...
Sarah Klein, PhD Sep 12, 2023

IHC-Validated p16INK4A Antibody: Jump-Start Your Senescence Research

p16INK4A has become a widely used marker for identifying senescent cells in tissue, yet interpreting...
Andrea Tu, PhD Apr 19, 2023

CST® Antibodies Validated on the Leica Microsystems Cell DIVE Multiplexed Imaging Solution

True innovation comes from collaboration–from bringing experts together to create techniques and too...
Alexandra Foley Mar 15, 2023

World Cancer Day: A Global Call to Action

Most people will either be directly or indirectly affected by a cancer diagnosis at some point in th...
Alexandra Foley Feb 6, 2023

Tools for Classifying Cells and Identifying Protein Localization

When do I want to classify cells? Why do I care where a protein localizes? These are actually two di...
Andrea Tu, PhD Jan 26, 2022

Immunology: Immunophenotyping Using Flow Cytometry or IHC

In the field of immunology and immuno-oncology, immunophenotyping is a technique that uses antibodie...
Chris Sumner Jun 30, 2021

Cancer Biomarker Antibody Selection for IHC

What are cancer biomarkers? Biomarkers are naturally occurring molecules that can be used as indicat...

Imaging Mass Cytometry: Endless Possibilities to Understand the Microenvironment of Disease

Understanding the microenvironment of disease is critical. Targeted cancer therapies may not be effe...

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar Aprahamian, PhD Sep 25, 2019

Demystifying Antibody Panel Design for Multiplex IHC

In recent years, immune checkpoints in the tumor microenvironment have been under intense study. If ...
Jen Z Oct 10, 2018

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