CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Menin-KMT2A Inhibitors: A Promising Approach to Acute Myeloid Leukemia (AML) Treatment

Accounting for about 80% of adult acute leukemias, acute myeloid leukemia (AML) is an aggressive for...
Homa Rahnamoun, PhD Oct 16, 2024

Validating a Monoclonal Antibody for the ADP-Ribosylation PTM

Protein adenosine diphosphate, or ADP-ribosylation, is a fascinating post-translational modification...

How to Detect Protein Methylation Using Proteomics

Protein methylation is a ubiquitous and critical post-translational modification (PTM) in eukaryotes...

AACR 2024 Highlights: The Era of Data and Omics Has Arrived

Spatial biology, cell therapy, targeted protein degradation, omics, and large-scale computational an...
Alexandra Foley Apr 24, 2024

Interrogating Immunometabolism in the TME Using a Metabolic Checkpoint

Previously considered distinct disciplines, the fields of immunology and metabolism are converging i...
Jianxin Xie, PhD Apr 17, 2024

Application-Specific Antibody Validation: Finding an IHC-Validated Claudin-6 mAb

Developing research antibodies is an extensive process that takes advantage of an animal’s adaptive ...
Alexandra Foley Nov 15, 2023

Breast Cancer Awareness Month: What You Need to Know About the BRCA Gene

Each year, approximately 13% of all women in the US and 25% of all women globally will feel their he...
Andrea Tu, PhD Oct 23, 2023

Faster Immuno-Oncology Research with Rapid T Cell Activation & Expansion

The success of immuno-oncology therapeutics has opened the door to novel cancer elimination strategi...
Andrea Tu, PhD Sep 20, 2023

High-Throughput 3D Assay Methods: Analysis of TGF-β Signaling

Spheroids and related three-dimensional (3D) cell models are rapidly gaining popularity among resear...
Alexandra Foley Aug 16, 2023

Cancer Immunotherapy Awareness Month: Fueling the Next Scientific Breakthrough

Did you know June is Cancer Immunotherapy Research Awareness Month? This year, we’ll celebrate 10 ye...
Andrea Tu, PhD Jun 21, 2023

Something to YAP About! Progress Targeting YAP/TAZ-TEAD Signaling in Cancer Research

YAP and its paralog TAZ (WWTR1), often referred to collectively as YAP/TAZ, are transcriptional co-a...
Antony Wood, PhD May 31, 2023

AACR 2023 Recap: Immunotherapy, CAR-T Cell Therapy Research Dominate

Last month marked the annual American Association for Cancer Research (AACR 2023) meeting, which gat...
Alexandra Foley May 10, 2023

IHC-Validated p16 INK4A Antibody: Jump-Start Your Senescence Research

Cell cycle regulation is vital to maintain tissue homeostasis and to prevent sustained proliferative...
Andrea Tu, PhD Apr 19, 2023

tRNA Modification by m7G MTase: Understanding its Role in Cancer and Developmental Disorders

Guest blogger Richard I. Gregory, PhD, is a professor at Harvard Medical School and Principal Invest...

World Cancer Day: A Global Call to Action

Most people will either be directly or indirectly affected by a cancer diagnosis at some point in th...
Alexandra Foley Feb 6, 2023

The Biopharma Trends to Watch in 2023, According to CST Scientists

Technological innovation leads to a deeper understanding of the natural world and the underlying cau...
Alexandra Foley Jan 18, 2023

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