Responsible Science Podcast: Episode 5 - The Next Generation


Posted by Chris S on Jun 20, 2018 3:10:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the final episode of our ‘Responsible Science’ series, we look forward with some of the most exciting innovators coming up through the ranks of academia, intent on making it a better and more responsible place as they go.

READ MORE >

Topics: Reproducibility

Responsible Science Podcast: Episode 4 - Publishing


Posted by Chris S on Jun 13, 2018 3:20:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the fourth episode of our ‘Responsible Science’, we dive deep into the world of the science dissemination industry – organizations whose role is to effectively communicate science to the wider world, in the most efficient, fair and considered way possible, and ensure science can keep moving forward.

READ MORE >

Topics: Reproducibility, Science Education

Responsible Science Podcast: Episode 3 - The Industry


Posted by Chris S on Jun 6, 2018 3:10:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the third episode of our ‘Responsible Science’, we dive deep into the world of scientific industry – companies that bring science out of the lab, into the real world, and turn a profit at the same time.

READ MORE >

Topics: Reproducibility, Science Education

Responsible Science Podcast: Episode 2 - The Disruptors


Posted by Chris S on May 23, 2018 3:10:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the second episode of our ‘Responsible Science’ series, we dive deep into the world of startups intent on making science more responsible through new technologies, modern mentalities, and brand new tools.

READ MORE >

Topics: Reproducibility, Science Education

Still in the Dark: AMD Patients Wait for Answers


Posted by Chris S on Apr 11, 2018 3:15:00 AM

In Mr. D’s sophomore English class, almost no subject was taboo or off limits. Even with our class projects, he encouraged us to pursue topics that truly interested us, and sometimes that meant having to educate Mr. D about something entirely new to him. But if your presentation included stunning visuals, you had to be prepared to paint a word picture. Macular degeneration rendered his otherwise healthy eyes all-but-useless. 

READ MORE >

Topics: Reproducibility, Neurodegeneration, Therapeutics, Immunotherapy

Webinar | Achieving Reproducibility: Don't Let Antibodies Be a Variable in Your Experiment


Posted by Chris S on Jan 10, 2018 6:30:00 AM

The importance of antibodies as tools in scientific research studies cannot be understated, yet these reagents have increasingly come under fire for their lack of reproducibility. Part of the issue is that the antibody market is composed of hundreds of vendors and resellers with varying definitions for validation and consistency. Cell Signaling Technology (CST) believes that antibody suppliers should be held accountable for the products they provide, but that vendors alone cannot solve the reproducibility “crisis." How antibodies are validated and used in the laboratory is a critical component to this process. Researchers need to be more attentive to following established protocols and leverage the expertise of the scientists who have developed and tested the product they are using. Journals need to be more active in enforcing existing policies regarding materials and methods or develop more clear-cut means to identify and describe the use of biological reagents in published research. During this webinar we will address the role vendors, researchers, and journals should play in minimizing irreproducibility. We will also outline CST’s antibody validation process, while highlighting steps all users should consider when selecting and using antibodies in their research.

READ MORE >

Topics: Antibody Performance, Antibody Validation, Webinars, Reproducibility

Discovery Through Validation: ChIP Assays


Posted by Carolyn P on Aug 2, 2017 8:45:00 AM

Cell Signaling Technology is proud to present the following On-Demand Webinar: 

The Use of Highly Validated Antibodies and Optimized ChIP Assays to Analyze Epigenetic Marks and Mechanism in DIsease

Sayura Aoyagi, Ph.D, CST Antibody Validation Scientist

READ MORE >

Topics: Cancer Research, Webinars, Reproducibility

Successful Immunofluorescence: Experimental Controls


Posted by Ken B on Mar 8, 2017 3:00:00 AM

 Part two of a four-part series on Immunofluorescence. Check out our posts on Validation and Fixation and Permeabilization

After months of hard work, your research has honed in on a hypothesis you can test with immunofluorescence (IF). You've chosen antibodies and performed pilot IF experiments (see The Importance of Validation), and the localization of the protein appears reasonable. But how can you be sure the IF data you've acquired represents real biological phenomena? We present two examples of experimental controls in this post.

READ MORE >

Topics: Protocols, Antibody Performance, Primary Antibodies, Antibody Validation, IF-IC, Post Translational Modification, Reproducibility

The Cost of a Failed Western Blot


Posted by Claire S on Sep 14, 2016 3:00:00 AM


Thinking about lab expenses isn’t as enjoyable as investigating your favorite signaling pathway. However, because research money is hard to come by, it is something that should be considered when picking your reagents for western blotting. It makes sense to keep the quality of your primary antibody in mind, because the success of the entire experiment depends on the antibody being reliable, specific, and sensitive. If the antibody does not perform as expected your experiment may fail . . . and the cost of a failed western blot may be more than you think.

READ MORE >

Topics: Antibody Performance, Antibody Validation, Western Blot, techniques, Reproducibility

The Reproducibility Crisis: An open letter from CST's Chief Scientific Officer


Posted by Carolyn P on Aug 10, 2016 3:00:00 AM

A Message from our Chief Scientific Officer, Roberto Polakiewicz, Ph.D.

The time is now for the scientific community to come together to respond to the challenges of reproducibility and to be part of the solution . . . 

READ MORE >

Topics: Reproducibility

Subscribe to Email Updates

Recent Posts