Video: Understanding Macrophages in the Tumor Microenvironment


Posted by Ken B on Sep 19, 2018 3:15:00 AM

Research trends in macrophage plasticity

It’s an exciting time for immuno-oncology research, as potential predictive biomarkers from an expanding collection of cell types are being pursued. Explore the plasticity of tumor-associated macrophages (TAMs) and challenges in distinguishing M1- versus M2- functional states in this 5-minute video featuring CST Developmental Scientist Sarah Klein, PhD. 

Can't see the embedded video? Click here to watch.

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Topics: Cancer Research, Immunology, Immunotherapy

From the Beaker to the Beach, pH Matters


Posted by Elias W on Sep 12, 2018 3:10:00 AM

Science is science, even if it's examining totally different aspects of nature like stem cell niches versus marine habitat niches. As a company grounded in science, CST values the efforts of non-profit organizations in our community that are working to protect our ecosystems.

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Topics: Corporate Social Responsibility, Sustainability

Tech Tips Video: Milk or BSA? Choosing a blocking protein for Western Blot


Posted by Ken B on Sep 5, 2018 3:00:00 AM

So you've set the timer to five minutes for the first of three TBST washes for your western blot membrane. Now what? Sure, you could check your email or social media for the 30th time before lunch. Or you could do something informative, like check out a CST Tech Tips video! This is a new short video series featuring the same scientists who develop and validate CST antibodies, here to offer insights and protocol tips.

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Topics: Protocols, Western Blot, techniques, Tech Tips

From Bench Scientist to Benchtop Support


Posted by Kaitlin M. on Aug 29, 2018 3:15:00 AM

I’m a Product Scientist at Cell Signaling Technology (CST). My typical work day no longer looks like my fellow scientists’ daily grind, and at times, I even find it difficult to describe in words what I do, but I’ll give it a shot!

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Topics: Antibody Performance, techniques, Science Education

Academia, Industry, and Entrepreneurship…oh my!


Posted by Tamar A. on Aug 22, 2018 3:10:00 AM

Tamar Aprahamian is an interesting study in the professional opportunities available for young scientists. She's worked in academia, industry, and most recently, founded a company of science writers called JetPub. She has been a contributor to our blog and was nice enough to share her story.

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Topics: Career Development, Science Education

Q&A: From Signaling Pathways to Career Pathways


Posted by Ken B on Aug 15, 2018 3:10:00 AM

Each summer, college and high school interns at CST get a chance to sample work life in a biotech environment. They are typically in the early stages of considering potential career paths, so what better time to set up a Q&A panel? Five CST employees shared some of their career development experiences during a recent “lunch and learn” session with the interns. Selections from the session have been transcribed and edited for brevity. –ed.

Q: Which do you like better, being on the bench or managing?

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Topics: Career Development

Targeting B-Cell Maturation Antigen (BCMA) Holds Promise for Multiple Myeloma Cure


Posted by Amrik S. on Aug 8, 2018 3:10:00 AM

Multiple myeloma (MM) is a type of hematopoietic malignancy characterized, in part, by bone pain, anemia, kidney failure, and recurring infections. The underlying mechanism that drives the disease is abnormal proliferation and accumulation of malignant plasma cells in the bone marrow that secrete large amounts of abnormal antibodies.

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Topics: Immunology, Therapeutics, Immunotherapy

ApoE4 and the Insulin Receptor — It's a Trap!


Posted by Richard C on Aug 1, 2018 3:15:00 AM

You might be surprised to learn that diabetes, a metabolic disease, may be linked to the neurodegenerative condition Alzheimer’s disease (AD). Diabetes is driven by altered insulin signaling from either insufficient insulin production (Type 1) or altered insulin receptor (IR) signaling (Type 2). In a seemingly unrelated disease, the human e4 allele of APOE is the strongest genetic risk factor for AD.

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Topics: Metabolism, Alzheimer's Disease, Neurodegeneration

Targeting Cancer Pathways - Tumor Metabolism and Proliferation


Posted by Carolyn P on Jul 25, 2018 3:10:00 AM


Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars will bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

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Topics: Cancer Research, Webinars

Signaling Is Like Wiring


Posted by Glen M on Jul 18, 2018 3:10:00 AM

I’d once heard a great analogy for the pursuit of knowledge: it’s akin to finding yourself in a pitch-black room. As you explore the contents of the room, finding objects and obstacles new to you, you happen upon not just a single doorknob, but many. Some are locked, others feel as though they might budge open given extreme effort, but one turns easily allowing you exit from the room. You come to realize that you were merely in one of countless rooms, halls, and corridors, all of which warrant exploration and understanding.

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Topics: Science Education

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