Hallmarks of Cancer: Enabling Replicative Immortality


Posted by Chris S on Apr 17, 2019 3:10:00 AM

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions.

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Topics: Cell Biology, Cancer Research

Introducing Cell Mentor


Posted by Chris S on Apr 10, 2019 3:15:00 AM

In collaboration with Cell Press, we are excited to announce a new educational resource that will make it easier for biology students and researchers to navigate their careers, get published, and strengthen their laboratory skills to enable experimental success. That new resource is called Cell Mentor™.

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Topics: Reproducibility, Career Development, Science Education, Tech Tips

Hallmarks of Cancer: Sustaining Proliferative Signaling


Posted by Chris S on Apr 3, 2019 3:15:00 AM

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.

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Topics: Cell Biology, Cancer Research

Hypoxia and Cancer – the role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis


Posted by Jianxin X. on Mar 27, 2019 3:10:00 AM

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP.

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Topics: Metabolism, Cell Biology

Hallmarks of Cancer: Inducing Angiogenesis Energetics


Posted by Chris S on Mar 20, 2019 3:15:00 AM

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.

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Topics: Cell Biology, Cancer Research

Necroptosis and Pyroptosis Add to Our Understanding of Apoptotic Cell Death


Posted by Gary K. on Mar 13, 2019 3:05:00 AM

Over the last 50 years laboratories have been able to demonstrate through experimentation the processes contributing to cell death. Early discoveries focused on morphological features of cell death and classifications into apoptosis and necrosis. Since then, there have been many more discoveries regarding the programmed cellular pathways contributing to apoptosis.

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Topics: Cell Biology

STR Profiling: What's growing in your incubator?


Posted by Hayley R. on Mar 6, 2019 3:15:00 AM

Cell lines are a crucial part of life science research and development. But did you know an estimated 18-36% of cell lines are believed to be misidentified or cross-contaminated with another cell line?

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Topics: techniques, Reproducibility

Hallmarks of Cancer: Deregulating Cellular Energetics


Posted by Chris S on Feb 27, 2019 3:15:00 AM

Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.

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Topics: Cell Biology, Cancer Research

Water Wise in the Lab


Posted by Elias W on Feb 20, 2019 3:10:00 AM

It probably comes as no surprise to you, since you work in a lab, that labs use five times the amount of water as a standard office building.

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Topics: Corporate Social Responsibility, CSR, Sustainability

Studying Post-translationally Modified Sites and Disease Variants with PhosphoSitePlus®


Posted by Florian G. on Feb 13, 2019 3:10:00 AM

Post-translational modifications (PTMs) are employed in the cell to alter protein function, and typically involve small chemical changes on the surface of the protein. The dynamic enzyme-catalyzed process of adding or subtracting PTMs mediates signaling in the cell. In other words, PTMs enhance protein-protein communication, enabling the cell to respond to internal or external signals.

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Topics: Post Translational Modification

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