B Cell Basics:  What a disease researcher needs to know


Posted by Tamar A. on Nov 18, 2020 3:15:00 AM

Changes in the activation of intracellular signaling networks downstream of B cell receptors (BCR) lead to altered B cell phenotypes. Knowledge of this process, and B cell plasticity, is essential for understanding how B cells modulate the immune response.

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Topics: Immunology

T Cell Basics: What a disease researcher needs to know


Posted by Tamar A. on Nov 11, 2020 3:00:00 AM

T cells are highly specialized lymphocytes that play a critical role in the cell-mediated arm of the adaptive immune response. Without them, our bodies would not be able to successfully fight off viral infections or scour tissues to eliminate some pre-cancerous cells.

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Topics: Immunology

COVID-19 and Fibrosis: Long-term damage beyond acute respiratory symptoms


Posted by Tony W on Nov 4, 2020 3:00:00 AM

At the time of writing the SARS-CoV-2 virus, responsible for COVID-19, has infected more than 28 million people worldwide, with nearly a million deaths attributed to the virus (source: Johns Hopkins Coronavirus Resource Center). One of the most striking aspects of SARS-CoV-2 infection is the diversity of symptoms that have been reported in patients [Kwon, 2020].

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Topics: Immunology

The Role of Autophagy and ER Stress in Viral Infection


Posted by Gary K. on Oct 28, 2020 3:00:00 AM

The regulation of ER stress and autophagy during viral infection is an important factor in the balance of virus and host survival. In this series, we look at pathways that are regulated through cellular responses to virus, as well as in response to virally encoded proteins. Infection of the coronaviruses SARS-CoV and SARS-CoV-2 causes severe lung injury with extensive damages to alveolar and bronchial epithelial cells, and produces extra-pulmonary damage.

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Topics: Cell Biology

The Role of Cell Death in Viral Infection


Posted by Gary K. on Oct 21, 2020 3:15:00 AM

The regulation of cell death during viral infection is an important factor in the balance of virus and host survival. In this series, we look at pathways that are regulated through cellular responses to virus, as well as in response to virally encoded proteins. Infection of the coronaviruses SARS-CoV and SARS-CoV-2 causes severe lung injury with extensive damages to alveolar and bronchial epithelial cells, and produces extra-pulmonary damage.

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Topics: Cell Biology

Cell Process: Which markers can be used to identify cellular senescence?


Posted by Tamar A. on Oct 14, 2020 3:00:00 AM

In response to a variety of environmental factors – like ionizing radiation, exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, or oncogene activation – cells may permanently cease proliferation and enter a state known as cellular senescence. Senescence occurs during normal developmental processes, in wound healing, and as a consequence of aging and age-related disease. Accordingly, understanding why senescence contributes to these processes may lead to the development of pro- and anti-senescence therapies to treat a range of diseases.

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Topics: Cell Biology

Cell Process: What role does senescence play in disease?


Posted by Tamar A. on Oct 7, 2020 3:00:00 AM

Cellular senescence occurs when cells cease proliferation and irreversibly exit the cell cycle. While this occurs as a normal process during development and tissue remodeling, senescence has also been linked to a general decline in tissue function during aging as well as a number of disease states. These include the progression of cancer, atherosclerosis, diabetes, and neurodegeneration. Accordingly, understanding why senescent cells impact these conditions and developing ways to target their removal may provide therapeutic value for the treatment of many human conditions.

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Topics: Cell Biology

Simplify the Identification of Pluripotent Stem Cells


Posted by Harald M and Chris S on Sep 30, 2020 3:00:00 AM

Reagent validation and experiment reproducibility are critical for advancing research of any scientific discipline. Achieving reproducible data in (induced) pluripotent stem cell research presents particularly formidable challenges, due to the biological complexity inherent to this research. The process of reprogramming cells and then subsequently directing them down different pathways of differentiation, is fraught with technical challenges, not least of which is the remarkable complexity of events and interactions required to coax cells towards the desired state.

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Topics: Workflow

Seeding Labs Gives Old Lab Equipment a Second Life


Posted by Chris S on Sep 23, 2020 3:00:00 AM

As stewards of the planet, we’re always trying to find ways to reduce our corporate carbon footprint and offset the environmental damage done through research. Operating a lab requires a lot of electricity: powering the freezers, microscopes, autostainers, and so much more. It all adds up. If you’re like us, you also want to find a way to give back, beyond the good that your research provides.

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Topics: Sustainability

Cell Process: What role do the telomeres play in senescence?


Posted by Tamar A. on Sep 16, 2020 3:00:00 AM

Senescence is a cellular state during which cells remain metabolically active, but irreversibly withdraw from the cell cycle and fail to respond to proliferation-inducing stimuli. Senescent cells influence a number of physiological and pathological processes from cancer to diabetes and aging. Accordingly, understanding why senescence contributes to these conditions may lead to the development of pro- and anti-senescence therapies to treat a range of diseases.

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Topics: Cell Biology

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