What Is Neurodegenerative Disease?


Posted by Chris S on Jan 20, 2021 3:00:00 AM

Neurodegeneration is marked by the progressive loss of neuronal function and structure leading to cognitive disabilities such as dementia. Neurodegenerative diseases are caused, in part, by the death of neurons and the homeostasis of glia and are associated with aging. Neurodegenerative diseases may occur due to age: Alzheimer's disease (AD), Parkinson's disease (PD); or due to genetic mutations which impact CNS cell function: Huntington's disease (HD), early onset AD or PD, and amyotrophic lateral sclerosis (ALS).
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Topics: Alzheimer's Disease, Neurodegeneration

Chasing Tau-biomarkers for Alzheimer’s Disease Part 2


Posted by Antonio V and Lei L on Jan 13, 2021 3:00:00 AM

The big question is: what plasma biomarker(s) could be used to accurately predict the severity of Alzheimer's Disease (AD) progression in patients? Because such molecules would have to be secreted from neurons in the brain, diffuse into the interstitial fluid (ISF), then the CSF, and finally the plasma, we would logically expect a largely attenuated signal in blood.

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Topics: Alzheimer's Disease, Neurodegeneration

2021 Preview


Posted by Chris S on Jan 6, 2021 3:00:00 AM

It’s the start of another exciting year of Lab Expectation articles. What can you expect from us in 2021?

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Case Study: Acetylated Lysine and Its Impact on Crohn’s Disease


Posted by Charles F and Josh N on Dec 16, 2020 3:00:00 AM

Nature Communications recently published a novel study from the laboratory of Daniel Figeys at the University of Ottowa, which begins to unravel the complexity of the microbiome of pediatric patients with Crohn’s disease or CD, which is a type of inflammatory bowel disease (IBD). It causes inflammation of your digestive tract, which can cause symptoms like abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

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Topics: Post Translational Modification, Proteomics

A Tale of Two Stains: Ponceau S vs Coomassie Blue


Posted by Caroline J and Misbah K on Dec 9, 2020 3:00:00 AM

You've just finished running your lysate sample by SDS-PAGE, so you're pretty confident your protein should have migrated at the right molecular weight and is ready to transfer to a membrane for detection by Western Blot. But what if it's not?

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Topics: Companion Reagents, techniques, Tech Tips

Chasing Tau-biomarkers for Alzheimer’s Disease Part 1


Posted by Antonio V and Lei L on Dec 2, 2020 9:30:00 AM

Dementia is an inevitable burden for many humans, prevailing under a broad umbrella not only in neurological disorders but also as the natural process of aging. Alzheimer’s disease (AD) represents the most common disease with several stages of dementia, which progresses over time. There are no tools or therapies to cure, prevent, or slow the progression of AD.

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Topics: Alzheimer's Disease

B Cell Basics:  What a disease researcher needs to know


Posted by Tamar A. on Nov 18, 2020 3:15:00 AM

Changes in the activation of intracellular signaling networks downstream of B cell receptors (BCR) lead to altered B cell phenotypes. Knowledge of this process, and B cell plasticity, is essential for understanding how B cells modulate the immune response.

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Topics: Immunology

T Cell Basics: What a disease researcher needs to know


Posted by Tamar A. on Nov 11, 2020 3:00:00 AM

T cells are highly specialized lymphocytes that play a critical role in the cell-mediated arm of the adaptive immune response. Without them, our bodies would not be able to successfully fight off viral infections or scour tissues to eliminate some pre-cancerous cells.

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Topics: Immunology

COVID-19 and Fibrosis: Long-term damage beyond acute respiratory symptoms


Posted by Tony W on Nov 4, 2020 3:00:00 AM

At the time of writing the SARS-CoV-2 virus, responsible for COVID-19, has infected more than 28 million people worldwide, with nearly a million deaths attributed to the virus (source: Johns Hopkins Coronavirus Resource Center). One of the most striking aspects of SARS-CoV-2 infection is the diversity of symptoms that have been reported in patients [Kwon, 2020].

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Topics: Immunology

The Role of Autophagy and ER Stress in Viral Infection


Posted by Gary K. on Oct 28, 2020 3:00:00 AM

The Role of Autophagy and ER Stress in Viral Infection

The regulation of ER stress and autophagy during viral infection is an important factor in the balance of virus and host survival. In this series, we look at pathways that are regulated through cellular responses to virus, as well as in response to virally encoded proteins. Infection of the coronaviruses SARS-CoV and SARS-CoV-2 causes severe lung injury with extensive damages to alveolar and bronchial epithelial cells, and produces extra-pulmonary damage.

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Topics: Cell Biology

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