Q&A: From Signaling Pathways to Career Pathways


Posted by Ken B on Aug 15, 2018 3:10:00 AM

Each summer, college and high school interns at CST get a chance to sample work life in a biotech environment. They are typically in the early stages of considering potential career paths, so what better time to set up a Q&A panel? Five CST employees shared some of their career development experiences during a recent “lunch and learn” session with the interns. Selections from the session have been transcribed and edited for brevity. –ed.

Q: Which do you like better, being on the bench or managing?

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Topics: Career Development

Targeting B-Cell Maturation Antigen (BCMA) Holds Promise for Multiple Myeloma Cure


Posted by Amrik S. on Aug 8, 2018 3:10:00 AM

Multiple myeloma (MM) is a type of hematopoietic malignancy characterized, in part, by bone pain, anemia, kidney failure, and recurring infections. The underlying mechanism that drives the disease is abnormal proliferation and accumulation of malignant plasma cells in the bone marrow that secrete large amounts of abnormal antibodies.

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Topics: Immunology, Therapeutics, Immunotherapy

ApoE4 and the Insulin Receptor — It's a Trap!


Posted by Richard C on Aug 1, 2018 3:15:00 AM

You might be surprised to learn that diabetes, a metabolic disease, may be linked to the neurodegenerative condition Alzheimer’s disease (AD). Diabetes is driven by altered insulin signaling from either insufficient insulin production (Type 1) or altered insulin receptor (IR) signaling (Type 2). In a seemingly unrelated disease, the human e4 allele of APOE is the strongest genetic risk factor for AD.

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Topics: Metabolism, Alzheimer's Disease, Neurodegeneration

Targeting Cancer Pathways - Tumor Metabolism and Proliferation


Posted by Carolyn P on Jul 25, 2018 3:10:00 AM


Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars will bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

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Topics: Cancer Research, Webinars

Signaling Is Like Wiring


Posted by Glen M on Jul 18, 2018 3:10:00 AM

I’d once heard a great analogy for the pursuit of knowledge: it’s akin to finding yourself in a pitch-black room. As you explore the contents of the room, finding objects and obstacles new to you, you happen upon not just a single doorknob, but many. Some are locked, others feel as though they might budge open given extreme effort, but one turns easily allowing you exit from the room. You come to realize that you were merely in one of countless rooms, halls, and corridors, all of which warrant exploration and understanding.

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Topics: Science Education

Mastering Phospho-Flow: Immune Cell Activation Webinar


Posted by Chris S on Jul 11, 2018 3:15:00 AM

To characterize activation of immune cells, measurement of intracellular signaling using phospho-specific antibodies combined with immune phenotyping using surface markers is ideal. Owing to the unique capability of flow cytometry to measure events at a single-cell level, “Phospho Flow” allows for the identification of rare signaling events during processes such as co-stimulatory signaling and manipulation of checkpoint inhibition. However, combining extracellular and intracellular antibodies in a flow protocol can present technical challenges. 
 
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Topics: Protocols, Flow

Patriotic Lab Bench


Posted by Chris S on Jul 4, 2018 3:15:00 AM

Our headquarters happens to be in the U.S. So we're taking some time to celebrate the Fourth of July. But also, Sunday was Canada Day for our northern neighbors and Bastille Day is coming up on July 14th. Happy Independence Day to anyone celebrating around the world. And to Australia, Cheers Mate, Happy Winter.

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Topics: Just for fun

Painless Publication: How to Write a Conference Abstract


Posted by Chris S on Jun 27, 2018 3:15:00 AM

Our previous blog post, “Painless Publication: How to Write a Journal Abstract,” walked you through the steps in writing the abstract for a journal article. Now we turn our focus to writing abstracts for conference proceedings. Although there are some similarities between these two types of abstracts, there are also some distinct considerations and approaches for conference abstracts.

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Topics: techniques, Q&A, Career Development, Science Education

Responsible Science Podcast: Episode 5 - The Next Generation


Posted by Chris S on Jun 20, 2018 3:10:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the final episode of our ‘Responsible Science’ series, we look forward with some of the most exciting innovators coming up through the ranks of academia, intent on making it a better and more responsible place as they go.

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Topics: Reproducibility

Responsible Science Podcast: Episode 4 - Publishing


Posted by Chris S on Jun 13, 2018 3:20:00 AM

We're excited to partner with Science: Disrupt to present a five-part podcast exploring what 'Responsible Science' means amidst the reproducibility crisis.

For the fourth episode of our ‘Responsible Science’, we dive deep into the world of the science dissemination industry – organizations whose role is to effectively communicate science to the wider world, in the most efficient, fair and considered way possible, and ensure science can keep moving forward.

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Topics: Reproducibility, Science Education

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