The Potential of Proteomics: A Clear Path to Discovery | Part II

Posted by Carolyn P on Feb 22, 2017 3:00:00 AM

See a real life example of how PTMScan technology can facilitate translational discovery. In this short video we describe how CST not only identified a major driver of NSCLC, which can respond to an FDA approved drug, but went a step further and developed an antibody that can be used to test which patients might be candidates for treatment. All thanks to the power of simplified proteomics.


Topics: Proteomics, PTMScan, techniques

Webinar - BioPlex: a protein interaction network created from thousands of protein immunopurifications

Posted by Claire S on Feb 15, 2017 7:00:00 AM

BioPlex: a protein interaction network created from thousands of protein immunopurifications

Steven Gygi, Ph.D
Professor in the Department of Cell Biology, Harvard Medical School

Protein-protein interactions form a network whose structure drives cellular function and whose organization informs all biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains


Topics: Webinars

Simplifying Proteomics - Part 2

Posted by Claire S on Feb 8, 2017 10:40:01 AM

Part 1 gave an overview on mass spectrometry-based proteomics. Now it’s time to talk about how this strategy can be used to identify peptides with post-translational modifications (PTM) from a complex biological sample.


Topics: Primary Antibodies, Post Translational Modification, Proteomics

How to Validate a Histone Modification Antibody

Posted by Carolyn P on Feb 1, 2017 3:00:00 AM

Antibodies targeted to histone modifications may bind non-specifically to similar, but off-target histone modifications. Conversely, their specific binding can be inhibited by steric hindrance from modifications on neighboring residues. Assays like ELISA, western blot, ChIP, and IF are commonly used to demonstrate antibody specificity and sensitivity, but they cannot clearly predict how an antibody will interact with nearby epitopes. As a result, they are of limited use when trying to validate an antibody to a histone modification target.


Topics: Antibody Performance, Antibody Validation, Epigenetics

CST Takes Leadership on UN COP21 Climate Targets

Posted by Elias W on Jan 25, 2017 3:00:00 AM

Cell Signaling Technology (CST) is proud to announce a plan to reduce our greenhouse gas (GHG) emissions to meet voluntary targets set by the 2015 COP21 Paris Climate Accords. As a company with a longstanding commitment to the environment through support of conservation, philanthropy, energy management, and sustainable packaging, we wanted to take independent action to meet COP21 climate targets. CST adopted these measures in November 2016 at a CST global leadership meeting that happened to coincide with the COP22 UN Climate talks in Marrakech, Morocco.


Topics: CSR, Sustainability

Beat the Blues of Writing a Scientific Rebuttal

Posted by Neha G on Jan 18, 2017 3:00:00 AM

You are glaring at your computer screen with a million thoughts in your head. You just got back the reviewers’ comments on your first manuscript. You don’t know where to start or how to respond. You are angry, frustrated, but mostly confused. The manuscript was supposed to be perfect, how could anyone find anything wrong with it? What you might not realize is that this reaction is normal . . . 


Topics: Just for fun, Q&A

The Potential of Proteomics: A Clear Path to Discovery

Posted by Carolyn P on Jan 11, 2017 3:00:00 AM

Whether your lab is well-versed and equipped to do Mass Spec analysis in house or your lab has never considered setting up a proteomics experiment before, the Proteomics group at CST has a solution to help clear the way.  Click below to watch the video and learn more.


Topics: Proteomics, PTMScan, techniques

Sowing the Seeds of Research Success in Developing Countries

Posted by Claire S on Jan 4, 2017 3:00:00 AM


Boston is famous for the Red Sox, baked beans, and for having a distinctive accent. What you may not know is that it’s also renowned for its thriving scientific community. With hundreds of colleges, biotech, and pharmaceutical companies in the Greater Boston area, what better location for Seeding Labs a non-profit organization whose mission is to help talented scientists in developing countries to conduct life-changing research. With help from the community they provide these scientists with the resources they need but might not have access to, including lab equipment, training, and access to key influencers in their field.


Topics: Corporate Social Responsibility

Happy New Year!

Posted by Tara W on Dec 28, 2016 3:00:00 AM


Season's Greetings from CST!

Posted by Ken B on Dec 21, 2016 3:00:00 AM

The holiday season is traditionally marked by festive choral music, decorated cookies, and in recent years, ugly sweater contests. CST employees get to experience all three traditions at the same time at the company’s yearly Holiday Concert.


Topics: Just for fun