Pathways to Metabolism


Posted by Chris S on Mar 3, 2021 3:00:00 AM

Cellular homeostasis is regulated by the coordinated activity of several key metabolic pathways. These processes, which include carbohydrate metabolism, lipid metabolism, glutamine metabolism, and nucleotide metabolism, maintain the energetic status of cells and provide the necessary building blocks to ensure proper cellular function. In turn, many of these metabolic pathways are regulated by extracellular signaling. For example, insulin acts as the major hormone controlling critical energetic functions like glucose and lipid metabolism by acting through its cognate receptor.

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Topics: Metabolism

Introducing the First Rising Black Scientists Awards Recipients


Posted by Chris S on Feb 24, 2021 3:00:00 AM

We’re excited to present the first-ever Rising Black Scientists Awards recipients. This will be an annual prize, and while we look forward to awarding many other worthy recipients in the future, there’s something extra special about celebrating the first.

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Topics: Corporate Social Responsibility

Targeting TIGIT for Immunotherapy and T Cell Exhaustion


Posted by Tamar A. on Feb 17, 2021 3:00:00 AM

The evolution of solid tumor cancer treatment has historically centered on a tripartite approach that includes surgery, chemotherapy or radiation therapy, and other tumor-specific treatments. More recently, the emergence of immunotherapy has signaled a potential paradigm shift in how tumors of these types are treated.

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Topics: Primary Antibodies, Immunology, Therapeutics, Immunotherapy

Neurodegeneration: Tau Protein and Neurofibrillary Tangles


Posted by Chris S on Feb 10, 2021 3:00:00 AM

Tau is a microtubule-associated protein expressed predominantly in the parts of the brain that function to stabilize axonal microtubules. Tau exists as 8 different isoforms and can be phosphorylated at a number of unique sites, which, in turn, decreases its ability to bind microtubules. While Tau is phosphorylated in normal, healthy brain, it becomes hyperphosphorylated in neurodegenerative diseases, including AD.

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Topics: Alzheimer's Disease, Neurodegeneration

Introduction to Metabolism


Posted by Chris S on Feb 3, 2021 3:00:00 AM

Cellular metabolism encompasses all of the chemical processes that occur within cells to maintain homeostasis and, in total, define their energetic status. These include biomolecular synthesis (anabolism) and biomolecular breakdown (catabolism).

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Topics: Metabolism

How S6 Ribosomal Protein (5G10) Rabbit mAb Can Help You With Your Immunofluorescence Staining


Posted by John B on Jan 27, 2021 3:00:00 AM

One antibody is used in our lab so often that we each keep our own bulk stock! This antibody is S6 Ribosomal Protein (5G10) Rabbit mAb #2217, which derives its utility from 5G10’s unique antigen. This blog will discuss how we use 5G10 as a readout for sample quality as well as an indicator of a well-executed IF experiment. In this way, 5G10 helps us produce the best quality data and images possible. It is our hope that you will be able to use these tips in your lab to increase confidence in your results.

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Topics: Antibody Performance, IF-IC

What Is Neurodegenerative Disease?


Posted by Chris S on Jan 20, 2021 3:00:00 AM

Neurodegeneration is marked by the progressive loss of neuronal function and structure leading to cognitive disabilities such as dementia. Neurodegenerative diseases are caused, in part, by the death of neurons and the homeostasis of glia and are associated with aging. Neurodegenerative diseases may occur due to age: Alzheimer's disease (AD), Parkinson's disease (PD); or due to genetic mutations which impact CNS cell function: Huntington's disease (HD), early onset AD or PD, and amyotrophic lateral sclerosis (ALS).
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Topics: Alzheimer's Disease, Neurodegeneration

Chasing Tau-biomarkers for Alzheimer’s Disease Part 2


Posted by Antonio V and Lei L on Jan 13, 2021 3:00:00 AM

The big question is: what plasma biomarker(s) could be used to accurately predict the severity of Alzheimer's Disease (AD) progression in patients? Because such molecules would have to be secreted from neurons in the brain, diffuse into the interstitial fluid (ISF), then the CSF, and finally the plasma, we would logically expect a largely attenuated signal in blood.

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Topics: Alzheimer's Disease, Neurodegeneration

2021 Preview


Posted by Chris S on Jan 6, 2021 3:00:00 AM

It’s the start of another exciting year of Lab Expectation articles. What can you expect from us in 2021?

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Case Study: Acetylated Lysine and Its Impact on Crohn’s Disease


Posted by Charles F and Josh N on Dec 16, 2020 3:00:00 AM

Nature Communications recently published a novel study from the laboratory of Daniel Figeys at the University of Ottowa, which begins to unravel the complexity of the microbiome of pediatric patients with Crohn’s disease or CD, which is a type of inflammatory bowel disease (IBD). It causes inflammation of your digestive tract, which can cause symptoms like abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

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Topics: Post Translational Modification, Proteomics

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