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The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Choosing the Right Ubiquitination Assay for Targeted Protein Degradation Research

In targeted protein degradation (TPD) drug discovery, confirming target ubiquitination is a pivotal ...
Gary Kasof, PhD Feb 25, 2026

Unlocking the Power of Ubiquitin: The Science Behind Targeted Protein Degradation

Ubiquitin is a small but powerful protein that functions in nearly all cellular signaling pathways a...
Gary Kasof, PhD Feb 18, 2026

Hallmarks of Cancer: Evading Growth Suppressors

Imagine driving down the highway with no brakes. That is essentially what happens when tumor cells l...
Gary Kasof, PhD Feb 11, 2026

Unlocking Protein-Level Insights in CAR-T Single Cell Analysis

Single cell RNA sequencing (scRNA-seq) has been a powerful tool to uncover heterogeneity in T cell p...
Majd Ariss, PhD Feb 4, 2026

Hallmarks of Cancer: Sustaining Proliferative Signaling

Cancer thrives by keeping cell proliferation stuck in the “on” position. Normally, cells wait for th...
Julian Arthur, PhD Jan 21, 2026

Hallmarks of Cancer: Senescent Cells

Senescence, a stable and generally irreversible state of cell cycle arrest, is a double-edged sword ...
Susan Keezer, PhD Jan 14, 2026

Hallmarks of Cancer: Resisting Cell Death

One of the defining characteristics of cancer cells is their ability to avoid programmed death—espec...
Gary Kasof, PhD Dec 17, 2025

Designing Multiplex IF Experiments for Neuroscience Research with Chimeric Antibodies

Host-based multiplex immunofluorescence (IF) of fixed frozen brain tissue is a powerful approach for...

Hallmarks of Cancer: Nonmutational Epigenetic Reprogramming

Nonmutational epigenetic reprogramming is a defining characteristic of cancer, whereby tumor cells a...
Curtis Desilets Nov 5, 2025

CiteAb Top 100: The Top-Ranked Recombinant Antibodies & Discovery Reagents

Each year, the CiteAb Top 100 Antibodies report highlights the reagents cited most frequently in pub...
Alexandra Foley Oct 31, 2025

Hallmarks of Cancer: Unlocking Phenotypic Plasticity

In 2022, an update was made to the Hallmarks of Cancer framework to expand beyond the eight hallmark...
Antony Wood, PhD Oct 22, 2025

Hallmarks of Cancer: Inducing or Accessing Vasculature (Angiogenesis)

Imagine a rapidly growing city—it needs roads, plumbing, and power lines to thrive. So too, do tumor...
Susan Kane, PhD Oct 8, 2025

Anything but Rabbit: Why Multiplex with Chimeric Antibodies?

It’s a refrain you’ve likely said before: “Give me anything but rabbit!” While rabbit antibodies are...
Supriya Singh, PhD Oct 1, 2025

Astrocyte Activation Markers for CNS Injury & Neurodegenerative Disease Research

Astrocytes play an important role in the central nervous system (CNS), supplying nutrients to neuron...
Supriya Singh, PhD Sep 24, 2025

Hallmarks of Cancer: Deregulating Cellular Metabolism

Cancer cells have a high demand for biomass—cellular components such as proteins, nucleic acids, and...
Jianxin Xie, PhD Sep 17, 2025

Protect Your Drug Development Pipeline: Don't Let Antibody Supply Disrupt Your Progress

For many researchers, choosing the right antibody for a project is one of the most important parts o...
Josh Nathan Sep 10, 2025

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