CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

Hallmarks of Cancer: Inducing Angiogenesis Energetics

Read More
All Posts

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.

18-CEL-47663-Blog-Hallmarks-Cancer-3-Inducing-Angiogenesis

Benign tumors can exist in a dormant state, which can be driven by inadequate access to sufficient blood supply. However, the "angiogenic switch" occurs when angiogenesis is activated in a dormant tumor and growth factors are secreted to induce sprouting and chemotaxis of endothelial cells toward the tumor mass.

Within the hypoxic environment of the tumor mass, hypoxia inducible factor-1 (HIF-1) is stabilized and activates the expression of multiple genes contributing to the angiogenic process, including vascular endothelial growth factor (VEGF) and fibroblast growth factor (bFGF), or platelet-derived growth factor (PDGF).

Click the angiogenesis pathway link to learn more about the related proteins implicated in this Hallmark of Cancer:

 - Angiogenesis Pathways

Checkout the complete guide to the Hallmarks of Cancer Research targets. Download the eBook Now.

  1.  Hanahan D, Weinberg RA (January 2000). "The Hallmarks of Cancer". Cell. 100 (1): 57–70. doi:10.1016/S0092-8674(00)81683-9
  2. Hanahan D, Weinberg RA (March 2011). "Hallmarks of Cancer: the next generation". Cell. 144 (5):646-74. doi: 10.1016/j.cell.2011.02.013.

The Hallmarks of Cancer were identified by Doctors Robert Weinberg and Douglas Hanahan and were originally published in Cell1. The authors propose the idea that the complexity of cancer can be broken down to smaller subsets of underlying principles. The information here pertains to one such subset. Other entries in this series explore the other known Hallmarks.

Chris Sumner
Chris Sumner
Chris Sumner was the Editor-in-Chief of Lab Expectations. When he's not reading/writing about curing disease, he's hiking in the woods, playing guitar, or searching for the world's best lobster roll.

Related Posts

Autophagy: It’s a Cell-Eat-Self World

If the thought of self-cannibalization is not appealing to you, you may not want to read the next sentenc...
Alexandra Foley May 22, 2024

Beyond Your Primary Antibody: What You Need for a Successful Chromatin Profiling Experiment

If you’ve performed CUT&RUN, CUT&Tag, or ChIP/ChIP-seq experiments, you know how important it is ...
Andrea Tu, PhD May 8, 2024

Mastering the Many Forms of Scientific Writing in Academia

In the science discipline, the art of communication is not a mere accessory—it is the linchpin of progres...
Alexandra Foley May 1, 2024