CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Cancer: Avoiding Immune Destruction

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. O...
Chris Sumner Jun 12, 2019

Who am I: Can a cellular identity crisis lead to cancer progression?

The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells tran...
Antony Wood, PhD May 29, 2019

What is Senescence?

Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age a...
Susan Keezer, PhD May 22, 2019

Hallmarks of Cancer: Evading Growth Suppressors

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways in...
Chris Sumner May 1, 2019

Hallmarks of Cancer: Enabling Replicative Immortality

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cell...
Chris Sumner Apr 17, 2019

Hallmarks of Cancer: Sustaining Proliferative Signaling

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals a...
Chris Sumner Apr 3, 2019

Hypoxia and Cancer: The role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions ...
Jianxin Xie, PhD Mar 27, 2019

Hallmarks of Cancer: Inducing Angiogenesis Energetics

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is th...
Chris Sumner Mar 20, 2019

Necroptosis and Pyroptosis Add to Our Understanding of Regulated Cell Death

Over the last 50 years, laboratories have been able to demonstrate through experimentation the proce...
Gary Kasof, PhD Mar 13, 2019

Hallmarks of Cancer: Deregulating Cellular Energetics

Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.
Chris Sumner Feb 27, 2019

Hallmarks of Cancer: Resisting Cell Death

One thing we know about cancer cells: they can resist death. They evade apoptosis, the mechanism tha...
Chris Sumner Jan 23, 2019

Missing Link: Why Do Insulin-producing Cells in Type 2 Diabetes Fail to Divide?

Type 2 diabetes is a growing epidemic, and is recognized as one of the most serious metabolic diseas...
Neha G Jan 17, 2018

Webinar | Advances in AMPK and Autophagy Signaling

Reuben Shaw, Ph.D Professor, Molecular and Cell Biology Laboratory, Deputy Director, Salk Cancer Cen...
Liana G Dec 20, 2017

Webinar | Highly Multiplexed Single Cell Analysis of Tumor Heterogeneity through Time and Space by Mass Cytometry

The study of the tumor ecosystem and its cell-to-cell communications is essential to enable an under...
Chris Sumner Jun 21, 2017

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