Hallmarks of Cancer: Activation Invasion and Metastasis


Posted by Chris S on Jul 17, 2019 3:15:00 AM

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.

READ MORE >

Topics: Cell Biology, Cancer Research

Immunotherapy & CAR-T Cells


Posted by Chris S on Jul 10, 2019 3:15:00 AM

Our immune system has the ability to detect and fight infectious pathogens. It can also detect when normal cells become cancerous and kill those cells, preventing cancer progression. But over time, cancers can evolve and evade the immune response.

READ MORE >

Topics: Immunotherapy

How to Choose Enzymatic or Sonication Protocol for ChIP


Posted by Chris S on Jun 26, 2019 3:10:00 AM

Researchers use chromatin immunoprecipitation, or ChIP, to identify and characterize protein-DNA interactions in the context of chromatin. ChIP experiments can use varying input samples, chromatin fragmentation methods, and provide ChIP-qPCR or ChIP-seq readouts.

READ MORE >

Topics: ChIP, Epigenetics

Video: Can you trust your immunohistochemistry results?


Posted by Chris S on Jun 19, 2019 3:05:00 AM

Immunohistochemistry, or IHC, remains the simplest method for detecting biomarker expression while maintaining spatial context within tissues. You know that getting reliable IHC staining results hinges on the specificity and performance of your antibody. These are high stakes experiments, and you want to be 100% confident your antibody will detect the target of interest.

Browse more how-to videos on research techniques, or click here to subscribe to CST's YouTube channel.

Can't see the above video? Click here to play.

READ MORE >

Topics: IHC

Hallmarks of Cancer: Avoiding Immune Destruction


Posted by Chris S on Jun 12, 2019 3:15:00 AM

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. One way cells do this is by hijacking normal mechanisms of immune checkpoint control and modulation of the innate immune response via STING.

READ MORE >

Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Evading Growth Suppressors


Posted by Chris S on May 1, 2019 3:10:00 AM

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Death Receptor Signaling (Apoptosis), both of which can ultimately lead to cell death, and reduction in tumor growth.

READ MORE >

Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Enabling Replicative Immortality


Posted by Chris S on Apr 17, 2019 3:10:00 AM

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions.

READ MORE >

Topics: Cell Biology, Cancer Research

Introducing Cell Mentor


Posted by Chris S on Apr 10, 2019 3:15:00 AM

In collaboration with Cell Press, we are excited to announce a new educational resource that will make it easier for biology students and researchers to navigate their careers, get published, and strengthen their laboratory skills to enable experimental success. That new resource is called Cell Mentor™.

READ MORE >

Topics: Reproducibility, Career Development, Science Education, Tech Tips

Hallmarks of Cancer: Sustaining Proliferative Signaling


Posted by Chris S on Apr 3, 2019 3:15:00 AM

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.

READ MORE >

Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Inducing Angiogenesis Energetics


Posted by Chris S on Mar 20, 2019 3:15:00 AM

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.

READ MORE >

Topics: Cell Biology, Cancer Research

Subscribe to Email Updates

Recent Posts