20 Years of Research, Reagents, and Lasting Relationships


Posted by Chris S on Oct 1, 2019 3:10:00 AM

Today marks 20 years of impact in scientific research and community support. We haven't done this alone — you’ve inspired us to think bigger and tackle greater challenges— we’ve Created Something Together. Thank you for standing with us.

 
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Topics: Corporate Social Responsibility

Hallmarks of Cancer: Genome Instability and Mutation


Posted by Chris S on Aug 28, 2019 3:10:00 AM

Not all cancer cells are equal, they evolve in response to selective pressure driven by accumulation of mutations. Cancer cells have to out-compete nearby cells for nutrients and other resources, avoid immune cell attack, and suppress apoptotic self-destruction.

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Topics: Cancer Immunology, Cell Biology

Hallmarks of Cancer: Tumor Promoting Inflammation


Posted by Chris S on Aug 21, 2019 3:15:00 AM

Cancer cells hijack inflammatory mechanisms to promote their own growth and survival. During a normal inflammatory response by the innate and adaptive immune system, immune cells carry out their designated task of engulfing and/or destroying foreign invaders.

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Topics: Cell Biology, Cancer Research

Webinar | Linking Senescence with DNA Damage and the Cell Cycle


Posted by Chris S on Aug 14, 2019 3:10:00 AM

Gain insight into the processes by which senescent cells contribute to tumor suppression and age-related pathologies. This webinar explores the impact of senescence on age-related dysfunction and chronic disease and introduces potential therapies targeting senescent cells.

 
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Topics: Cell Biology, Webinars

Hallmarks of Cancer: Activation Invasion and Metastasis


Posted by Chris S on Jul 17, 2019 3:15:00 AM

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.

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Topics: Cell Biology, Cancer Research

Immunotherapy & CAR-T Cells


Posted by Chris S on Jul 10, 2019 3:15:00 AM

Our immune system has the ability to detect and fight infectious pathogens. It can also detect when normal cells become cancerous and kill those cells, preventing cancer progression. But over time, cancers can evolve and evade the immune response.

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Topics: Immunotherapy

How to Choose Enzymatic or Sonication Protocol for ChIP


Posted by Chris S on Jun 26, 2019 3:10:00 AM

Researchers use chromatin immunoprecipitation, or ChIP, to identify and characterize protein-DNA interactions in the context of chromatin. ChIP experiments can use varying input samples, chromatin fragmentation methods, and provide ChIP-qPCR or ChIP-seq readouts.

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Topics: ChIP, Epigenetics

Video: Can you trust your immunohistochemistry results?


Posted by Chris S on Jun 19, 2019 3:05:00 AM

Immunohistochemistry, or IHC, remains the simplest method for detecting biomarker expression while maintaining spatial context within tissues. You know that getting reliable IHC staining results hinges on the specificity and performance of your antibody. These are high stakes experiments, and you want to be 100% confident your antibody will detect the target of interest.

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Topics: IHC

Hallmarks of Cancer: Avoiding Immune Destruction


Posted by Chris S on Jun 12, 2019 3:15:00 AM

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. One way cells do this is by hijacking normal mechanisms of immune checkpoint control and modulation of the innate immune response via STING.

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Topics: Cell Biology, Cancer Research

Hallmarks of Cancer: Evading Growth Suppressors


Posted by Chris S on May 1, 2019 3:10:00 AM

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Death Receptor Signaling (Apoptosis), both of which can ultimately lead to cell death, and reduction in tumor growth.

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Topics: Cell Biology, Cancer Research

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