Demystifying Multiplex IHC


Posted by Jen Z on Oct 10, 2018 3:15:00 AM

In recent years, immune checkpoint proteins in the tumor microenvironment have been under intense study. If you work in the immuno-oncology field, chances are you are either performing multiplex IHC (mIHC) or would like to. Ultimately, a multiplexed image like the one featured here provides a multi-layered depiction of a tumor, such that each antibody corresponds to a different fluorescent signal. If you want to detect more targets in your IHC, but aren’t sure how to design a panel of antibodies and fluorophores for mIHC, we’ll walk you through the process in this post.

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Topics: Immunology, IHC, mIHC, Cancer Research, techniques

2018 Nobel Prize Awarded to Immunotherapy Pioneers


Posted by Cell Signaling Technology on Oct 3, 2018 3:00:00 AM

Earlier this week, Dr. James Allison and Dr. Tasuku Honjo were announced as joint winners of the 2018 Nobel Prize in Physiology or Medicine for their work in the field of immunotherapy and checkpoint immune regulation. Their studies have sparked decades of clinical advances, and changed the future of cancer therapy. A webinar presented by Dr. Allison in conjunction with Dr. Gordon Freeman and Dr. Philip Gotwals is featured in this week's blog post.

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Topics: Immunotherapy, Cancer Research, Cancer Immunology, Webinars

Video: Understanding Macrophages in the Tumor Microenvironment


Posted by Ken B on Sep 19, 2018 3:15:00 AM

Research trends in macrophage plasticity

It’s an exciting time for immuno-oncology research, as potential predictive biomarkers from an expanding collection of cell types are being pursued. Explore the plasticity of tumor-associated macrophages (TAMs) and challenges in distinguishing M1- versus M2- functional states in this 5-minute video featuring CST Developmental Scientist Sarah Klein, PhD. 

Can't see the embedded video? Click here to watch.

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Topics: Immunotherapy, Immunology, Cancer Research

Targeting Cancer Pathways - Tumor Metabolism and Proliferation


Posted by Carolyn P on Jul 25, 2018 3:10:00 AM


Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars will bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

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Topics: Cancer Research, Webinars

GPNMB: A Promising Immunotherapeutic Target for Triple Negative Breast Cancer


Posted by Amrik S. on Apr 4, 2018 3:00:00 AM

The last few years have witnessed several breakthroughs in the immuno-oncology space. Treatments that harness the body’s immune system to fight cancer have transitioned from speculation to offering endless possibilities for drug discovery. Of these treatments, therapeutic monoclonal antibodies are positioned at the forefront of the immunotherapy revolution, and the FDA has approved several of these monoclonal antibodies to treat cancer.

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Topics: Cancer Research, Cancer Immunology, Therapeutics, Medicine, antibody-drug conjugates, Immunotherapy

Antibody Company of the Year (2018)


Posted by Chris S on Feb 7, 2018 6:15:00 AM

We as scientists learn from each success and failure. Sometimes it takes many failures to achieve success. And some discoveries are made with no fanfare, far from the spotlight. Other times, a good day’s work is even sweeter when you realize someone noticed!

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Topics: Reproducility, Cancer Research, Antibody Performance, Antibody Validation

Targeting Cancer Pathways - Tumor Resistance


Posted by Carolyn P on Oct 18, 2017 6:00:00 AM


Cell Signaling Technology is proud to partner with the Koch Institute at MITScience, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

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Topics: Cancer Research, Webinars

Webinar - Immunolabeling for Neurodegenerative Disease


Posted by Carolyn P on Oct 4, 2017 3:00:00 AM

This two part webinar features Dr. Li Huei Tsai from the Picower Institute at MIT and CST Development Scientist, Dr. Raphael Rozenfeld. Dr. Tsai discusses how modeling systems can be combined with immunolabeling and imaging techniques to unlock the mystery of Alzheimer's Disease. Dr Rozenfeld describes the rigorous validation procedure our antibodies undergo before being release, with special emphasis placed on our neuroscience portfolio. Check out the abstracts below and then click on the button to watch their exciting presentations.

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Topics: Cancer Research

Journal Club:  Hippo pathway and intestinal stem cell regeneration


Posted by Liana G on Sep 20, 2017 3:00:00 AM

Journal Club: YAP-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer.

The article we have chosen was published in the October 29th, 2015 issue of the journal Nature by Gregorieff et al., from the Lunenfeld Tanenbaum Research Institute and University of Toronto, Ontario Canada. The article is entitled YAP-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer, and focuses on stem cell dynamics within the intestinal epithelium, the most rapidly self-renewing tissue in adult mammals.

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Topics: Cancer Research, Journal Club

Discovery Through Validation: ChIP Assays


Posted by Carolyn P on Aug 2, 2017 8:45:00 AM

Cell Signaling Technology is proud to present the following On-Demand Webinar: 

The Use of Highly Validated Antibodies and Optimized ChIP Assays to Analyze Epigenetic Marks and Mechanism in DIsease

Sayura Aoyagi, Ph.D, CST Antibody Validation Scientist

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Topics: Cancer Research, Webinars, Reproducibility

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