Hallmarks of Cancer: Evading Growth Suppressors


Posted by Chris S on May 1, 2019 3:10:00 AM

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Death Receptor Signaling (Apoptosis), both of which can ultimately lead to cell death, and reduction in tumor growth.

READ MORE >

Topics: Cell Biology, Cancer Research

General Tips for Successful Cell Culture


Posted by Dan D on Apr 24, 2019 3:10:00 AM

Culturing cells in the lab? Following these tips will add to your success and help you avoid wasted time or the dreaded cell contamination!

READ MORE >

Topics: techniques, Science Education, Tech Tips

Hallmarks of Cancer: Enabling Replicative Immortality


Posted by Chris S on Apr 17, 2019 3:10:00 AM

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions.

READ MORE >

Topics: Cell Biology, Cancer Research

Introducing Cell Mentor


Posted by Chris S on Apr 10, 2019 3:15:00 AM

In collaboration with Cell Press, we are excited to announce a new educational resource that will make it easier for biology students and researchers to navigate their careers, get published, and strengthen their laboratory skills to enable experimental success. That new resource is called Cell Mentor™.

READ MORE >

Topics: Reproducibility, Career Development, Science Education, Tech Tips

Hallmarks of Cancer: Sustaining Proliferative Signaling


Posted by Chris S on Apr 3, 2019 3:15:00 AM

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.

READ MORE >

Topics: Cell Biology, Cancer Research

Hypoxia and Cancer – the role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis


Posted by Jianxin X. on Mar 27, 2019 3:10:00 AM

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP.

READ MORE >

Topics: Metabolism, Cell Biology

Hallmarks of Cancer: Inducing Angiogenesis Energetics


Posted by Chris S on Mar 20, 2019 3:15:00 AM

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.

READ MORE >

Topics: Cell Biology, Cancer Research

Necroptosis and Pyroptosis Add to Our Understanding of Apoptotic Cell Death


Posted by Gary K. on Mar 13, 2019 3:05:00 AM

Over the last 50 years laboratories have been able to demonstrate through experimentation the processes contributing to cell death. Early discoveries focused on morphological features of cell death and classifications into apoptosis and necrosis. Since then, there have been many more discoveries regarding the programmed cellular pathways contributing to apoptosis.

READ MORE >

Topics: Cell Biology

STR Profiling: What's growing in your incubator?


Posted by Hayley R. on Mar 6, 2019 3:15:00 AM

Cell lines are a crucial part of life science research and development. But did you know an estimated 18-36% of cell lines are believed to be misidentified or cross-contaminated with another cell line?

READ MORE >

Topics: techniques, Reproducibility

Hallmarks of Cancer: Deregulating Cellular Energetics


Posted by Chris S on Feb 27, 2019 3:15:00 AM

Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.

READ MORE >

Topics: Cell Biology, Cancer Research

Subscribe to Email Updates

Recent Posts