Hallmarks of Cancer: Activation Invasion and Metastasis


Posted by Chris S on Jul 17, 2019 3:15:00 AM

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.

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Topics: Cell Biology, Cancer Research

Immunotherapy & CAR-T Cells


Posted by Chris S on Jul 10, 2019 3:15:00 AM

Our immune system has the ability to detect and fight infectious pathogens. It can also detect when normal cells become cancerous and kill those cells, preventing cancer progression. But over time, cancers can evolve and evade the immune response.

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Topics: Immunotherapy

How to Choose Enzymatic or Sonication Protocol for ChIP


Posted by Chris S on Jun 26, 2019 3:10:00 AM

Researchers use chromatin immunoprecipitation, or ChIP, to identify and characterize protein-DNA interactions in the context of chromatin. ChIP experiments can use varying input samples, chromatin fragmentation methods, and provide ChIP-qPCR or ChIP-seq readouts.

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Topics: ChIP, Epigenetics

Video: Can you trust your immunohistochemistry results?


Posted by Chris S on Jun 19, 2019 3:05:00 AM

Immunohistochemistry, or IHC, remains the simplest method for detecting biomarker expression while maintaining spatial context within tissues. You know that getting reliable IHC staining results hinges on the specificity and performance of your antibody. These are high stakes experiments, and you want to be 100% confident your antibody will detect the target of interest.

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Topics: IHC

Hallmarks of Cancer: Avoiding Immune Destruction


Posted by Chris S on Jun 12, 2019 3:15:00 AM

Some cancer cells adapt mechanisms to evade detection and destruction by the host's immune system. One way cells do this is by hijacking normal mechanisms of immune checkpoint control and modulation of the innate immune response via STING.

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Topics: Cell Biology, Cancer Research

If I could only see what’s going on inside your brain...


Posted by Richard C on Jun 5, 2019 3:15:00 AM

For generations of neuroscientists, using immunohistochemistry to study the brain in its anatomical context typically meant imaging a tiny slice at a time. Using the traditional method of taking micron thick sections, fixing, staining, imaging, and, finally, stitching all the slices together, is a super laborious task, especially for large tissues. But what if you could "look" into an intact mouse brain and identify specific cells and eliminate all of the slicing and stitching?

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Topics: IHC, Alzheimer's Disease, Neurodegeneration

Who am I: Can a cellular identity crisis lead to cancer progression?


Posted by Antony W on May 29, 2019 3:10:00 AM

            The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells transform into cells with more mesenchymal characteristics, was first described by pioneering Harvard biologist Elizabeth “Betty” Hay in the 1980s.

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Topics: Cell Biology, Cancer Research

What is Senescence?


Posted by Susan K on May 22, 2019 3:15:00 AM

Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to the normal aging process as well as age-related disorders. The link between senescence, aging, and age-related pathologies, including cancer, neurodegeneration, and metabolic and cardiovascular diseases have largely fueled the senescence research field.

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Topics: Cell Biology

Building a Brighter Future with Energy Savings


Posted by Elias W on May 15, 2019 3:10:00 AM

CST is proud of our forward progress on UN COP 21 climate change goals as we are well into year three of our climate pledge. While the science behind our range of research-grade antibodies and reagents may be complex, the science and methodologies to combat climate change is very straightforward. It comes down to simple subtraction and addition, albeit on a tremendous scale.

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Topics: Corporate Social Responsibility

Need cell type and function? Use flow cytometry!


Posted by Tamar A. on May 8, 2019 3:15:00 AM

What is flow cytometry and how is it used?

Flow cytometry enables you to save time and analyze many characteristics of your cells in one experiment, using classic principles of antibody detection.

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Topics: Flow

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