CST BLOG

The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Antibody Validation - Binary Strategy

A binary approach is one of the best ways to evaluate antibody specificity. By testing an antibody i...
Katie Crosby Jan 22, 2020

Immunology: How does our immune system protect us?

Scientists and medical professionals have been studying what makes us sick and the myriad mechanisms...
April Lowell, PhD Jan 8, 2020

Tissue Clearing from a Microscope Enthusiast’s Perspective

Biological imaging data has massive potential in terms of complexity of experiment and richness of d...
Ginny Bain, PhD Oct 30, 2019

IMC: Endless Possibilities to Understand the Microenvironment of Disease

Understanding the microenvironment of disease is critical. Targeted cancer therapies may not be effe...

The Researcher's Guide to the Hallmarks of Cancer Research Targets

If you haven’t heard already, it’s CST’s 20th anniversary. Woohoo! You could say this year is kind o...
Chris Sumner Oct 9, 2019

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar Aprahamian, PhD Sep 25, 2019

How to Prepare a ChIP-seq DNA Library

Chromatin immunoprecipitation sequencing (ChIP-seq) is a flexible and powerful technique used by res...
Tamar Aprahamian, PhD Sep 18, 2019

Hallmarks of Cancer: Tumor-Promoting Inflammation

Cancer cells hijack inflammatory mechanisms to promote their own growth and survival. During a norma...
Chris Sumner Aug 21, 2019

Taking Out the Mitochondria in Parkinson’s Disease

We’re proud to partner with The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to move Pa...
Richard Cho, PhD Jul 31, 2019

The BAFfling Complexity of the BAF Complex in Cancer

How do cells dynamically regulate access to their tightly packed DNA to control gene expression and ...
Curtis Desilets Jul 24, 2019

Hallmarks of Cancer: Activating Invasion and Metastasis

Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes...
Chris Sumner Jul 17, 2019

Enzymatic vs Sonication: Optimizing Chromatin Prep for Successful ChIP

Part one of this series described the importance of including proper controls in your ChIP protocols...
Carolyn P Jun 26, 2019

Tissue Clearing Imaging Methods for Whole, Intact Brain Imaging

For generations of neuroscientists, using immunohistochemistry to study the brain in its anatomical ...
Richard Cho, PhD Jun 5, 2019

Pathways to Cancer: Epithelial-Mesenchymal Transition

The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells tran...
Antony Wood, PhD May 29, 2019

Need cell type and function? Use flow cytometry

What is flow cytometry and how is it used? Flow cytometry enables you to save time and analyze many ...
Tamar Aprahamian, PhD May 8, 2019

Hallmarks of Cancer: Evading Growth Suppressors

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways in...
Chris Sumner May 1, 2019

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