CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST), where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Cancer: Evading Growth Suppressors

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways in...
Chris Sumner May 1, 2019

General Tips for Successful Cell Culture

Culturing cells in the lab? Following these tips will add to your success and help you avoid wasted ...
Dan D Apr 24, 2019

Hallmarks of Cancer: Enabling Replicative Immortality

Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cell...
Chris Sumner Apr 17, 2019

Hallmarks of Cancer: Sustaining Proliferative Signaling

Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals a...
Chris Sumner Apr 3, 2019

Hypoxia and Cancer: The role of HIF-1α in oxygen sensing, metabolism, and tumorigenesis

Molecular oxygen (O2) is an essential element for metazoan life. Among its many roles, O2 functions ...
Jianxin Xie, PhD Mar 27, 2019

Hallmarks of Cancer: Inducing Angiogenesis Energetics

Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is th...
Chris Sumner Mar 20, 2019

Necroptosis and Pyroptosis Add to Our Understanding of Regulated Cell Death

Over the last 50 years, laboratories have been able to demonstrate through experimentation the proce...
Gary Kasof, PhD Mar 13, 2019

STR Profiling: What's Growing in Your Incubator?

Cell lines are a crucial part of life science research and development. But did you know an estimate...
Hayley R Mar 6, 2019

Hallmarks of Cancer: Deregulating Cellular Energetics

Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.
Chris Sumner Feb 27, 2019

Water Wise in the Lab

It probably comes as no surprise to you, since you work in a lab, that labs use five times the amoun...
Elias Witman Feb 20, 2019

Studying Post-translationally Modified Sites and Disease Variants with PhosphoSitePlus®

Post-translational modifications (PTMs) are employed in the cell to alter protein function, and typi...
Florian Gnad, PhD Feb 13, 2019

More Than a Phenotype: A Guide to Assessing Tumor-infiltrating Immune Cell Types and Functions

Although the rise of cancer immunotherapy may seem meteoric to many, the history goes back over 100 ...
Emily A Feb 6, 2019

What makes an antibody monoclonal, polyclonal, or recombinant?

When you’re shopping for antibodies, there are so many factors to consider. For example, will it wor...
Chris Sumner Jan 30, 2019

Hallmarks of Cancer: Resisting Cell Death

One thing we know about cancer cells: they can resist death. They evade apoptosis, the mechanism tha...
Chris Sumner Jan 23, 2019

Can I accelerate my ELISA results?

Running an ELISA can be a pain. Identifying pairs for an ELISA is a tedious business, and that’s bef...
Chris Sumner Jan 16, 2019

When should I use flow cytometry for signaling instead of western blot?

Flow cytometry enables quantitative analysis of protein expression, signaling states, and physical c...
Chris Sumner Jan 9, 2019

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