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The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Hallmarks of Antibody Validation: Heterologous Strategy

For antigenic targets where expression of the protein is very low or unknown, the use of recombinant...
Katie CrosbyApr 1, 2020

Fibrosis: When Wound Healing Turns to Disease

Fibrosis is a disease that is characterized by scarring and hardening of tissues and organs. Fibrosi...
Susan Keezer, PhDMar 25, 2020

Hallmarks of Validation - Multiple Antibody Strategy

A multiple antibody strategy is a powerful approach to antibody validation. One of the most common m...
Katie CrosbyMar 18, 2020

CiteAb Awards: Antibody Supplier of the Decade & Antibody Supplier Succeeding in Alzheimer's Research

We’re honored to win two CiteAb awards in 2020: Antibody Supplier of the Decade and Antibody Supplie...
Chris SumnerMar 11, 2020

Hallmarks of Validation - Ranged Strategy

While a binary approach is one of the more desirable ways to evaluate antibody specificity, binary m...
Katie CrosbyFeb 19, 2020

Immunology: How does the innate immune system work?

As we touched on in a previous blog post, the innate immune system is an important part of our body'...
April Lowell, PhDFeb 12, 2020

Hallmarks of Antibody Validation - Binary Strategy

A binary approach is one of the best ways to evaluate antibody specificity. By testing an antibody i...
Katie CrosbyJan 22, 2020

Immunology: How does our immune system protect us?

Scientists and medical professionals have been studying what makes us sick and the myriad mechanisms...
April Lowell, PhDJan 8, 2020

Tissue Clearing from a Microscope Enthusiast’s Perspective

Biological imaging data has massive potential in terms of complexity of experiment and richness of d...
Ginny Bain, PhDOct 30, 2019

Imaging Mass Cytometry: Endless Possibilities to Understand the Microenvironment of Disease

Understanding the microenvironment of disease is critical. Targeted cancer therapies may not be effe...

Dual Staining Mouse CD8 and FoxP3 with Confidence

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visu...
Tamar Aprahamian, PhDSep 25, 2019

How to Prepare a ChIP-seq DNA Library

Chromatin immunoprecipitation sequencing (ChIP-seq) is a flexible and powerful technique used by res...
Tamar Aprahamian, PhDSep 18, 2019

Taking Out the Mitochondria in Parkinson’s Disease

We’re proud to partner with The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to move Pa...
Richard Cho, PhDJul 31, 2019

The BAFfling Complexity of the BAF Complex in Cancer

How do cells dynamically regulate access to their tightly packed DNA to control gene expression and ...
Curtis DesiletsJul 24, 2019

Enzymatic vs Sonication: Optimizing Chromatin Prep for Successful ChIP

Part one of this series described the importance of including proper controls in your ChIP protocols...
Carolyn PJun 26, 2019

Tissue Clearing Imaging Methods for Whole, Intact Brain Imaging

For generations of neuroscientists, using immunohistochemistry to study the brain in its anatomical ...
Richard Cho, PhDJun 5, 2019

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