Targeting TIGIT for Immunotherapy and T Cell Exhaustion

Posted by Tamar A. on Feb 17, 2021 3:00:00 AM

The evolution of solid tumor cancer treatment has historically centered on a tripartite approach that includes surgery, chemotherapy or radiation therapy, and other tumor-specific treatments. More recently, the emergence of immunotherapy has signaled a potential paradigm shift in how tumors of these types are treated.


Topics: Primary Antibodies, Immunology, Therapeutics, Immunotherapy

Tools to Help Researchers Fight COVID-19

Posted by Maxine M on Feb 26, 2020 3:15:00 AM

In order to quickly defeat SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2,previously named as nCoV) and stop the epidemic, diagnosis and treatment are especially important. As of January 31, 2020, SARS-CoV-2 nucleic acid detection kits from 7 companies have been approved for SARS-CoV-2 detection (data source: NMPA). Meanwhile, researchers are still working hard to develop effective treatments.


Topics: Cell Biology, Therapeutics, Medicine

Targeting B-Cell Maturation Antigen (BCMA) Holds Promise for Multiple Myeloma Cure

Posted by Amrik S. on Aug 8, 2018 3:10:00 AM

Multiple myeloma (MM) is a type of hematopoietic malignancy characterized, in part, by bone pain, anemia, kidney failure, and recurring infections. The underlying mechanism that drives the disease is abnormal proliferation and accumulation of malignant plasma cells in the bone marrow that secrete large amounts of abnormal antibodies.


Topics: Immunology, Therapeutics, Immunotherapy

Still in the Dark: AMD Patients Wait for Answers

Posted by Chris S on Apr 11, 2018 3:15:00 AM

In Mr. D’s sophomore English class, almost no subject was taboo or off limits. Even with our class projects, he encouraged us to pursue topics that truly interested us, and sometimes that meant having to educate Mr. D about something entirely new to him. But if your presentation included stunning visuals, you had to be prepared to paint a word picture. Macular degeneration rendered his otherwise healthy eyes all-but-useless. 


Topics: Reproducibility, Neurodegeneration, Therapeutics, Immunotherapy

GPNMB: A Promising Immunotherapeutic Target for Triple Negative Breast Cancer

Posted by Amrik S. on Apr 4, 2018 3:00:00 AM

The last few years have witnessed several breakthroughs in the immuno-oncology space. Treatments that harness the body’s immune system to fight cancer have transitioned from speculation to offering endless possibilities for drug discovery. Of these treatments, therapeutic monoclonal antibodies are positioned at the forefront of the immunotherapy revolution, and the FDA has approved several of these monoclonal antibodies to treat cancer.


Topics: Cancer Immunology, Cancer Research, Therapeutics, Medicine, antibody-drug conjugates, Immunotherapy

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