CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology (CST) where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Trim-Away: Rapid, Easy, and Specific Protein Degradation

Foundational approaches for studying protein function in living models—gene editing and RNA interfer...

Antibodies for Identifying the Protein Modification O-GlcNAc

Rajan Burt, Samuel Myers, and colleagues from the La Jolla Institute for Immunology, Broad Institute...

Analyzing PTM Activation State Using Western Blotting

Post-translational modifications (PTMs) are a critical regulatory mechanism that allows cells to tig...
Andrea Tu, PhD Dec 8, 2021

Case Study: Acetylated Lysine and Its Impact on Crohn’s Disease

Nature Communications recently published a novel study from the laboratory of Daniel Figeys at the U...
Charles F and Josh N Dec 16, 2020

Studying Post-translationally Modified Sites and Disease Variants with PhosphoSitePlus®

Post-translational modifications (PTMs) are employed in the cell to alter protein function, and typi...
Florian G Feb 13, 2019

Myth-busting for ChIP/ChIP-seq: Using Mono vs Polyclonal Antibodies

Researchers who run a lot of chromatin immunoprecipitation "ChIP" assays—maybe even your advisor—mig...
Kenneth Buck, PhD Sep 26, 2018

Have You Ever Wondered: What's The Lowdown on Phospho-Specific Antibodies?

Early exploration of unmapped biological signaling pathways was carried out using radiolabeled phosp...
Kenneth Buck, PhD Jul 26, 2017

Successful Immunofluorescence: Experimental Controls

Part two of a four-part series on successful immunofluorescence. Read Part 1: The Importance of Vali...
Kenneth Buck, PhD Mar 8, 2017

Simplifying Proteomics - Part I

After sequencing of the human genome was complete, it was time to roll up our sleeves and get starte...
Claire S Jun 15, 2016

Simplifying Proteomics - Part 3

Part 1 and part 2 introduced mass spectrometry-based proteomic methods, like PTMScan®, for the study...
Claire S Dec 9, 2015

Simplifying Proteomics - Part 2

Part 1 gave an overview on mass spectrometry-based proteomics. Now, it’s time to talk about how this...
Claire S Dec 2, 2015

PTMScan Tutorial Video

Simplifying proteomics Part 1 introduced mass spectrometry-based proteomics for profiling post-trans...
Claire S Jun 10, 2015

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