CST BLOG: Lab Expectations

The official blog of Cell Signaling Technology® (CST) where we discuss what to expect from your time at the bench, share tips, tricks, and information.

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Trim-Away: Rapid, Easy, and Specific Protein Degradation

Foundational approaches for studying protein function in living models—gene editing and RNA interfer...

When Specificity Is Simply Sweet

Rajan Burt, Samuel Myers, and colleagues from the La Jolla Institute for Immunology, Broad Institute...

Post-Translational Modifications: Analyzing Protein Activation State

Post-translational modifications (PTMs) are a critical regulatory mechanism that allows cells to tig...
Andrea T Dec 8, 2021

Case Study: Acetylated Lysine and Its Impact on Crohn’s Disease

Nature Communications recently published a novel study from the laboratory of Daniel Figeys at the U...
Charles F and Josh N Dec 16, 2020

Studying Post-translationally Modified Sites and Disease Variants with PhosphoSitePlus®

Post-translational modifications (PTMs) are employed in the cell to alter protein function, and typi...
Florian G Feb 13, 2019

Myth-busting for ChIP/ChIP-seq: Mono vs. Poly

Researchers who run a lot of chromatin immunoprecipitation "ChIP" assays – maybe even your advisor –...
Neha G and Ken B Sep 26, 2018

Have You Ever Wondered: What's The Lowdown on Phospho-Specific Antibodies?

Early exploration of unmapped biological signaling pathways was carried out using radiolabeled phosp...
Kenneth Buck, PhD Jul 26, 2017

Successful Immunofluorescence: Experimental Controls

 Part two of a four-part series on Immunofluorescence. Check out our posts on Validation and Fixatio...
Kenneth Buck, PhD Mar 8, 2017

Simplifying Proteomics - Part I

After sequencing of the human genome was complete, it was time to roll up our sleeves and get starte...
Claire S Jun 15, 2016

Simplifying Proteomics - Part 3

Part 1 and part 2 introduced mass spectrometry-based proteomic methods, like PTMScan®, for the study...
Claire S Dec 9, 2015

Simplifying Proteomics - Part 2

Part 1 gave an overview on mass spectrometry-based proteomics. Now it’s time to talk about how this ...
Claire S Dec 2, 2015

PTMScan Tutorial Video

Simplifying proteomics part 1 introduced mass spectrometry-based proteomics for profiling post-trans...
Claire S Jun 10, 2015

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