For generations of neuroscientists, using immunohistochemistry to study the brain in its anatomical context typically meant imaging a tiny slice at a time. Using the traditional method of taking micron thick sections, fixing, staining, imaging, and, finally, stitching all the slices together, is a super laborious task, especially for large tissues. But what if you could "look" into an intact mouse brain and identify specific cells and eliminate all of the slicing and stitching?
The process of epithelial-mesenchymal transition (EMT), whereby differentiated epithelial cells transform into cells with more mesenchymal characteristics, was first described by pioneering Harvard biologist Elizabeth “Betty” Hay in the 1980s.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to the normal aging process as well as age-related disorders. The link between senescence, aging, and age-related pathologies, including cancer, neurodegeneration, and metabolic and cardiovascular diseases have largely fueled the senescence research field.
Topics: Cell Biology
CST is proud of our forward progress on UN COP 21 climate change goals as we are well into year three of our climate pledge. While the science behind our range of research-grade antibodies and reagents may be complex, the science and methodologies to combat climate change is very straightforward. It comes down to simple subtraction and addition, albeit on a tremendous scale.
Topics: Corporate Social Responsibility
What is flow cytometry and how is it used?
Flow cytometry enables you to save time and analyze many characteristics of your cells in one experiment, using classic principles of antibody detection.
Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Death Receptor Signaling (Apoptosis), both of which can ultimately lead to cell death, and reduction in tumor growth.
Culturing cells in the lab? Following these tips will add to your success and help you avoid wasted time or the dreaded cell contamination!
Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions.
In collaboration with Cell Press, we are excited to announce a new educational resource that will make it easier for biology students and researchers to navigate their careers, get published, and strengthen their laboratory skills to enable experimental success. That new resource is called Cell Mentor™.
Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.