The Guide to the Hallmarks of Cancer Research Targets


Posted by Chris S on Oct 9, 2019 3:15:00 AM

If you haven’t heard already, it’s CST’s 20th anniversary. Woohoo! You could say this year is kind of a big deal for us. We have a lot to celebrate. However, once we started listing the successes over the years, we realized that we are most proud of what you – the researchers worldwide – have accomplished using our reagents. After all, we don’t live in a vacuum. We exist to serve you and enable important discoveries and the development of cures.

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Topics: Cell Biology, Cancer Research

20 Years of Research, Reagents, and Lasting Relationships


Posted by Chris S on Oct 1, 2019 3:10:00 AM

Today marks 20 years of impact in scientific research and community support. We haven't done this alone — you’ve inspired us to think bigger and tackle greater challenges— we’ve Created Something Together. Thank you for standing with us.

 
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Topics: Corporate Social Responsibility

Dual Staining Mouse CD8 and FoxP3 with Confidence


Posted by Tamar A. on Sep 25, 2019 3:15:00 AM

For decades, immunohistochemistry (IHC) has been a powerful technique for the investigation and visualization of cellular components in their native histological context. IHC has served as an important tool in medicine – enabling the diagnosis of complex pathological conditions – and in basic research to advance the understanding of key biological processes. 

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Topics: IHC, Immunology

Preparing a ChIP-seq DNA library. Where do I start?


Posted by Tamar A. on Sep 18, 2019 3:15:00 AM

Chromatin immunoprecipitation sequencing (ChIP-seq) is a flexible and powerful technique used by researchers to elucidate how gene regulation is involved with different biological events and with the progression of various conditions like cancer and neurodegenerative diseases.

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Topics: ChIP, Epigenetics

Hallmarks of Cancer: Genome Instability and Mutation


Posted by Chris S on Aug 28, 2019 3:10:00 AM

Not all cancer cells are equal, they evolve in response to selective pressure driven by accumulation of mutations. Cancer cells have to out-compete nearby cells for nutrients and other resources, avoid immune cell attack, and suppress apoptotic self-destruction.

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Topics: Cancer Immunology, Cell Biology

Hallmarks of Cancer: Tumor Promoting Inflammation


Posted by Chris S on Aug 21, 2019 3:15:00 AM

Cancer cells hijack inflammatory mechanisms to promote their own growth and survival. During a normal inflammatory response by the innate and adaptive immune system, immune cells carry out their designated task of engulfing and/or destroying foreign invaders.

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Topics: Cell Biology, Cancer Research

Webinar | Linking Senescence with DNA Damage and the Cell Cycle


Posted by Chris S on Aug 14, 2019 3:10:00 AM

Gain insight into the processes by which senescent cells contribute to tumor suppression and age-related pathologies. This webinar explores the impact of senescence on age-related dysfunction and chronic disease and introduces potential therapies targeting senescent cells.

 
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Topics: Cell Biology, Webinars

Visualize and Understand Protein Co-expression during EMT


Posted by Tamar A. on Aug 7, 2019 3:10:00 AM

Careful planning and the fine tuning of experimental protocols are key to ensuring clear, interpretable scientific results. This is especially true for immunohistochemistry (IHC) studies, where each step in the often multiday process – from tissue preparation to stain development – can significantly impact the final outcome and analysis. Often, the simultaneous examination of multiple antigens is required to address specific scientific questions, which further complicates IHC protocol development. A general understating of the steps necessary to optimize IHC for multiple targets is essential to achieve reliable results. So, what are these steps?

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Topics: IHC

Taking Out the Mitochondria in Parkinson’s Disease


Posted by Richard C and Yiying Z on Jul 31, 2019 3:15:00 AM

Parkinson’s disease (PD) is a neurodegenerative disease marked by loss of dopaminergic neurons in the substantia nigra. Mutations in the gene that encodes a ubiquitin ligase PARK2/Parkin are known to cause autosomal recessive forms of familial PD1. Parkin plays a key role in mitochondrial homeostasis by regulating a specialized form of autophagy called mitophagy, the clearance of defective or damaged mitochondria by lysosomes2.

How does altered mitochondrial homeostasis contribute to PD?

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Topics: Proteomics, Neurodegeneration

BAFfling Epigenetic Remodeling in Disease States


Posted by Curtis D on Jul 24, 2019 3:10:00 AM

The massive amount of DNA in the human body is truly baffling. Stretched end to end, the DNA from a single somatic cell is about 2 meters in length, doing the same for all the DNA in the average human would reach the end of the solar system and back!

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Topics: Epigenetics

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