Taking Out the Mitochondria in Parkinson’s Disease

Posted by Richard C and Yiying Z on Jul 31, 2019 3:15:00 AM

Parkinson’s disease (PD) is a neurodegenerative disease marked by loss of dopaminergic neurons in the substantia nigra. Mutations in the gene that encodes a ubiquitin ligase PARK2/Parkin are known to cause autosomal recessive forms of familial PD1. Parkin plays a key role in mitochondrial homeostasis by regulating a specialized form of autophagy called mitophagy, the clearance of defective or damaged mitochondria by lysosomes2.

How does altered mitochondrial homeostasis contribute to PD?


Topics: Proteomics, Neurodegeneration

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